Metabolic Dysfunction in Obese Hispanic Women with Polycystic Ovary Syndrome

The study concluded that obese Hispanic women with polycystic ovary syndrome (PCOS) have a higher risk of metabolic disorders compared to their non-Hispanic white counterparts, despite having similar age and BMI. The cross-sectional observational study involved 60 women with PCOS, including 17 Hispanic, 22 non-Hispanic black, and 21 non-Hispanic white women. Hispanic women exhibited a higher waist-to-hip ratio, greater insulin resistance, and more atherogenic lipid profiles. Notably, after adjusting for waist-to-hip ratio, some differences became non-significant, but Hispanic women still had higher low-density lipoprotein particle numbers and smaller high-density lipoprotein sizes. These findings suggest the need for focused management of metabolic parameters in Hispanic women with PCOS, although the study's small sample size and its focus on obese women limit the generalizability of the results. The study was supported by the National Institutes of Health and there were no conflicts of interest reported by the authors.