Comparison of Clinical and Metabolic Effects of Metformin and Pioglitazone in Polycystic Ovary Syndrome

January 2016 in “ Indian journal of endocrinology and metabolism ”

Karoon Shahebrahimi, Nasrin Jalilian, Nasrin Bazgir, Mansour Rezaei

metformin pioglitazone polycystic ovary syndrome PCOS insulin resistance androgen levels hyperinsulinemia hyperandrogenemia systolic blood pressure menses pregnancy lipid profiles clomiphene citrate ovulation Glucophage Actos clomiphene Clomid

TLDR Both metformin and pioglitazone improve PCOS symptoms, but pioglitazone is a good alternative for those who can't take metformin.

The study compared the clinical and metabolic effects of metformin and pioglitazone in women with polycystic ovary syndrome (PCOS) through multiple studies. Both medications significantly improved insulin resistance and androgen levels. Metformin was effective in reducing hyperinsulinemia, hyperandrogenemia, systolic blood pressure, and facilitating normal menses and pregnancy. Pioglitazone showed benefits in insulin and androgen abnormalities, especially in obese patients, and improved lipid profiles. Combining these drugs with treatments like clomiphene citrate could enhance ovulation in clomiphene-resistant women. Both drugs were beneficial, but their effects varied based on individual patient characteristics.

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Research cited in this study

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Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

815 citations, April 2010 in “The Journal of Clinical Endocrinology & Metabolism”

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

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Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

research Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

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