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GlossaryPioglitazone

medication for type 2 diabetes that increases insulin sensitivity

Pioglitazone, also known by the brand name Actos, is a medication used to manage type 2 diabetes. It works by increasing the body's sensitivity to insulin, helping to control blood sugar levels. While primarily used for diabetes, it has also been studied for potential benefits in other conditions, including certain types of hair loss like alopecia, due to its anti-inflammatory and insulin-sensitizing properties.

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Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

research Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

33 citations, October 2013 in “Journal of The American Academy of Dermatology”

Pioglitazone usually doesn't effectively treat or cure lichen planopilaris.

research Comparison of Clinical and Metabolic Effects of Metformin and Pioglitazone in Polycystic Ovary Syndrome

26 citations, January 2016 in “Indian journal of endocrinology and metabolism”

Both metformin and pioglitazone improve PCOS symptoms, but pioglitazone is a good alternative for those who can't take metformin.

research A Randomized Placebo-Controlled Study on the Effects of Pioglitazone on Cortisol Metabolism in Polycystic Ovary Syndrome

24 citations, April 2008 in “Fertility and sterility”

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

research Reversible Hair Loss in a Patient With Cicatricial Alopecia: A Case of Regrowth Associated With Pioglitazone Use

1 citations, August 2022 in “JAAD case reports”

Pioglitazone use was linked to hair regrowth in a patient with permanent hair loss from cicatricial alopecia.

research Assessment of Quality of Life and Therapeutic Outcomes of Metformin, Pioglitazone with Myoinositol and Ethinylestradiol Cyproterone in Ethnic Pakistani Women with Polycystic Ovary Syndrome

January 2019

Different medications improved various PCOS symptoms and quality of life in Pakistani women, but did not significantly help with excessive hair growth.

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community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 2 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Anger and frustration as I finally learn my diagnosis.

in Female 6 upvotes 1 year ago

A young female diagnosed with Lichen planopilaris (LPP) experienced years of misdiagnosis and ineffective treatments, including a hair transplant and other procedures. She is considering litigation due to the misdiagnosis and has learned that LPP is chronic, hair loss can be stopped with ongoing medication, but lost hair cannot regrow.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.