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GlossaryAcanthosis Nigricans

skin condition with dark, thick, velvety patches

Acanthosis Nigricans (AN) is a skin condition characterized by dark, thick, and velvety patches, typically found in body folds and creases such as the neck, armpits, and groin. It is often associated with insulin resistance, obesity, and hormonal disorders, and can sometimes be a sign of an underlying health issue like type 2 diabetes or, in rare cases, cancer.

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research Acanthosis Nigricans, Insulin Resistance, And Cutaneous Virilism

43 citations, May 1988 in “British Journal of Dermatology”

Patients with acanthosis nigricans often have insulin resistance and signs of increased male hormones, but treatment targeting these male hormones is generally ineffective.

research Acanthosis Nigricans and the Metabolic Syndrome

30 citations, September 2017 in “Clinics in Dermatology”

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

research Implications of a Clinically Ignored Site of Acanthosis Nigricans: The Knuckles

9 citations, October 2014 in “Experimental and Clinical Endocrinology & Diabetes”

Knuckle Acanthosis Nigricans is common in Latin American youth and may indicate early insulin resistance, especially in those with normal weight.

research Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome

7 citations, January 2015 in “Case reports in endocrinology”

The document concludes that HAIR-AN syndrome should be considered when a patient shows severe hyperandrogenism and insulin resistance after excluding tumors.

Acanthosis Nigricans in the Knuckles: An Early, Accessible, Straightforward, and Sensitive Clinical Tool to Predict Insulin Resistance

research Acanthosis Nigricans in the Knuckles: An Early, Accessible, Straightforward, and Sensitive Clinical Tool to Predict Insulin Resistance

6 citations, January 2018 in “Dermato-endocrinology”

Darkened knuckles can be an early sign of insulin resistance.

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