No Metabolic Impact of Surgical Normalization of Hyperandrogenism in Postmenopausal Women with Ovarian Androgen-Secreting Tumors

    May 2012 in “ Clinical Endocrinology ”
    Carla Pelusi, G. Forlani, Laura Zanotti, Alessandra Gambineri, Renato Pasquali
    Image of study
    TLDR Surgery to lower high testosterone in postmenopausal women with certain ovarian tumors doesn't significantly affect their metabolism.
    The study investigated the effects of surgically reducing high testosterone levels in five postmenopausal women with ovarian androgen-secreting tumors (OAST), aged 63 ± 5 years. Fifteen age-matched and BMI-matched postmenopausal women without hyperandrogenism were used as controls. Although testosterone and gonadotrophin levels normalized after the patients underwent oophorectomy, there were no significant changes in body weight, insulin sensitivity, or most other metabolic parameters. Only one diabetic patient showed a moderate decrease in haemoglobin Alc. The study suggests that the metabolic consequences of high testosterone levels in postmenopausal women with OAST may be less significant than previously thought, and that more research is needed to fully understand the relationship between hyperandrogenism and metabolic function.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 10 results

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  36 upvotes 6 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Dutasteride is amazing even for women with FAGA!

      in Female  151 upvotes 6 months ago
      Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

      community I wish I were a man so bad. Life is cruel

      in Female  210 upvotes 3 days ago
      A woman with androgenetic alopecia uses Dutasteride and Bicalutamide but feels devastated due to increased sensitivity to DHT. She considers wigs, Minoxidil, and seeks advice on options like spironolactone, hair transplants, and therapy.

      community Spironolactine Update: 2 months (34, Female)

      in Female  22 upvotes 9 years ago
      A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 1 year ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

    Similar Research

    5 / 1000+ results