Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

    Kathryn A. Martin, R. Jeffrey Chang, David A. Ehrmann, Lourdes Ibáñez, Rogerio A. Løbo, Robert L. Rosenfield, Jerry Shapiro, Víctor M. Montori, Brian A. Swiglo
    TLDR Treat significant hirsutism with medication and hair removal; use birth control pills first, adding antiandrogens if needed.
    The 2008 guidelines for evaluating and treating hirsutism in premenopausal women emphasized a thorough clinical assessment to identify underlying causes like PCOS or adrenal hyperplasia. The Ferriman-Gallwey score was recommended to quantify hair growth. Oral contraceptives were suggested as the primary treatment, with antiandrogens like spironolactone added if needed after 6 months. Antiandrogen monotherapy was discouraged without adequate contraception. Insulin-lowering drugs and flutamide were not recommended due to limited efficacy and potential risks. For hair removal, laser/photoepilation was preferred, with eflornithine cream for faster results. The guidelines stressed individualized treatment plans, considering patient preferences and potential side effects.
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