Studysummary This review examined various treatments for hirsutism and found low to very low quality evidence suggesting that flutamide and spironolactone may help reduce hair growth, while metformin was ineffective.
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Research cited in this study 101
- Interventions for Hirsutism (Excluding Laser and Photoepilation Therapy Alone) Cochrane library · 2015
- Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study Journal of Pediatric and Adolescent Gynecology · 2014
- Therapy of Endocrine Disease: Treatment of Hirsutism in Polycystic Ovary Syndrome European journal of endocrinology · 2013
- Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology and Metabolism · 2013
- Possible Efficacy of Lavender and Tea Tree Oils in the Treatment of Young Women Affected by Mild Idiopathic Hirsutism PubMed · 2013
- How to Diagnose and Treat Women with Excessive Hair Dermatologic clinics · 2012
- Interventions for Female Pattern Hair Loss Cochrane Database of Systematic Reviews · 2012
- An Overview of Unwanted Female Hair British journal of dermatology/British journal of dermatology, Supplement · 2011
- Epidemiology, Diagnosis, and Management of Hirsutism: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society Human reproduction update · 2011
- Effectiveness of Ethinylestradiol/Chlormadinone Acetate in Treating Dermatological Conditions Related to High Androgen Levels American Journal of Clinical Dermatology · 2011
- The Hirsute Woman: Challenges in Evaluation and Management Endocrine Practice · 2011
- Lifestyle Changes in Women with Polycystic Ovary Syndrome Cochrane library · 2011
- Current Standards in the Diagnostics and Therapy of Hair Diseases - Hair Consultation Journal der Deutschen Dermatologischen Gesellschaft · 2011
- Medical Treatment of Hirsutism in Women Current medicinal chemistry · 2010
- Hirsutism: Diagnosis and Management Gender Medicine · 2010
- Parenteral and Oral Cyproterone Acetate Treatment in Severe Hirsutism Gynecologic and obstetric investigation · 2010
- Comprehensive Clinical Management of Hirsutism Gynecological endocrinology · 2010
- An Open Randomized Comparative Study of an Oral Contraceptive Containing Ethinyl Estradiol and Cyproterone Acetate with and without the GnRH Analogue Goserelin in the Long-Term Treatment of Hirsutism Gynecologic and obstetric investigation · 2010
- Clinical, Metabolic, and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, and Placebo-Controlled Trial Gynecological Endocrinology · 2010
- European Consensus on the Evaluation of Women Presenting with Excessive Hair Growth European journal of dermatology/EJD. European journal of dermatology · 2009
- A Comparative Study of Diane-35 Plus Spironolactone and Diane-35 Plus Finasteride in Cases of Hirsutism and Acne International Journal of Endocrinology and Metabolism · 2009
- Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women Dermatology · 2009
- Spearmint Herbal Tea Has Significant Anti-Androgen Effects in Polycystic Ovarian Syndrome: A Randomized Controlled Trial PTR. Phytotherapy research/Phytotherapy research · 2009
- Spironolactone Versus Placebo or in Combination with Steroids for Hirsutism and/or Acne Cochrane library · 2009
- Double-Blind, Randomized, Placebo-Controlled Trial of a Cream Containing the Stryphnodendron Adstringens (Martius) Coville Bark Extract for Suppressing Terminal Hair Growth Journal of the European Academy of Dermatology and Venereology · 2009
- A Comparison Between Finasteride, Flutamide, and Finasteride Plus Flutamide Combination in the Treatment of Hirsutism Journal of Endocrinological Investigation · 2009
- The Clinical Evaluation of Hirsutism Dermatologic therapy · 2008
- Medical Treatment of Hirsutism Dermatologic therapy · 2008
- Androgens and Hair Growth Dermatologic Therapy · 2008
- Insulin Sensitizers for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials The Journal of Clinical Endocrinology & Metabolism · 2008
- Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008
- Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2008
- Effects of Two Estroprogestins Containing Ethinylestradiol 30 μg and Drospirenone 3 mg and Ethinylestradiol 30 μg and Chlormadinone 2 mg on Skin and Hormonal Hyperandrogenic Manifestations Gynecological endocrinology · 2008
- A Systematic Review of Commonly Used Medical Treatments for Hirsutism in Women Clinical endocrinology · 2007
- A Randomized Bilateral Vehicle-Controlled Study of Eflornithine Cream Combined with Laser Treatment Versus Laser Treatment Alone for Facial Hirsutism in Women Journal of the American Academy of Dermatology · 2007
- Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline The Journal of Clinical Endocrinology and Metabolism · 2006
- Randomized, Double-Blind Clinical Evaluation of the Efficacy and Safety of Topical Eflornithine HCl 13.9% Cream in the Treatment of Women with Facial Hair International Journal of Dermatology · 2006
- Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36 Gynecological Endocrinology · 2006
- Hirsutism New England journal of medicine/The New England journal of medicine · 2005
- Topical Finasteride in Hirsutism: A Double-Blind Randomized Clinical Trial on Adult Women Journal of Research in Medical Sciences · 2005
- Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women Fertility and Sterility · 2004
- Finasteride Versus Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism International journal of gynaecology and obstetrics · 2004
- A Comparison Between Spironolactone and Spironolactone Plus Finasteride in the Treatment of Hirsutism European journal of endocrinology · 2004
- Androgen Excess in Women: Experience with Over 1000 Consecutive Patients The Journal of Clinical Endocrinology and Metabolism · 2004
- Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003
- Spironolactone Versus Placebo or in Combination with Steroids for Hirsutism and Acne 2003
- Cyproterone Acetate for Hirsutism Cochrane library · 2003
- Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2003
- The Evaluation and Management of Hirsutism Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology · 2003
- Hirsutism: A Psychological Analysis Journal of health psychology · 2003
- Use of Cyproterone Acetate, Finasteride, and Spironolactone to Treat Idiopathic Hirsutism Fertility and Sterility · 2003
- Antihirsutism Activity of Fennel (Fruits of Foeniculum Vulgare) Extract – A Double-Blind Placebo Controlled Study Phytomedicine · 2003
- The Benefits of Finasteride for Hirsute Women with Polycystic Ovary Syndrome or Idiopathic Hirsutism Gynecological Endocrinology · 2003
- Comparison of Spironolactone and Spironolactone Plus Finasteride in the Treatment of Hirsutism Fertility and Sterility · 2002
- Comparison of High-Dose Finasteride (5 mg/day) Versus Low-Dose Finasteride (2.5 mg/day) in the Treatment of Hirsutism European journal of endocrinology · 2002
- The Effect of Metformin on Hirsutism in Polycystic Ovary Syndrome European journal of endocrinology · 2002
- The Effect of Two Combined Oral Contraceptives Containing Either Drospirenone or Cyproterone Acetate on Acne and Seborrhea PubMed · 2002
- Management of Unwanted Hair in Females Clinical and experimental dermatology · 2001
- Comparison of Diane 35 and Diane 35 Plus Finasteride in the Treatment of Hirsutism Fertility and Sterility · 2001
- Finasteride Cream in Hirsutism Endocrine Practice · 2001
- A Prospective, Randomized Trial Comparing Flutamide (250 mg/d) and Finasteride (5 mg/d) in the Treatment of Hirsutism Fertility and Sterility · 2000
- Comparison of Diane 35 and Diane 35 Plus Finasteride in the Treatment of Hirsutism Fertility and Sterility · 2000
- Antiandrogen Drugs Lower Serum Prostate-Specific Antigen Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2000
- Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial The Journal of Clinical Endocrinology and Metabolism · 2000
- Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial The Journal of Clinical Endocrinology and Metabolism · 2000
- A Comparative Study of a Gonadotropin-Releasing Hormone Agonist and Finasteride on Idiopathic Hirsutism PubMed · 2000
- Comparison of Finasteride Versus Flutamide in the Treatment of Hirsutism European journal of endocrinology · 1999
- Comparison of Finasteride and Flutamide in the Treatment of Idiopathic Hirsutism Fertility and Sterility · 1999
- A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1999
- Treatment of Hirsutism: Comparisons Between Different Antiandrogens with Central and Peripheral Effects Fertility and sterility · 1999
- Comparison of Cyproterone Acetate Plus Ethinyl Estradiol and Finasteride in the Treatment of Hirsutism Journal of Endocrinological Investigation · 1998
- Finasteride for Hirsutism: A Dose Finding Study PubMed · 1998
- Comparison of Finasteride Versus Spironolactone in the Treatment of Idiopathic Hirsutism Fertility and Sterility · 1997
- Finasteride And Flutamide In The Treatment Of Hirsutism PubMed · 1997
- Gonadotrophin-Releasing Hormone Agonist Therapy for Hirsutism Is as Effective as High Dose Cyproterone Acetate but Results in a Longer Remission Human reproduction · 1997
- Treatment of Hirsutism by Finasteride and Flutamide in Women with Polycystic Ovary Syndrome Gynecological Endocrinology · 1997
- Finasteride in the Treatment of Hirsutism: New Therapeutic Perspectives Fertility and Sterility · 1996
- Comparison of a Gonadotropin-Releasing Hormone Agonist and a Low Dose Oral Contraceptive Given Alone or Together in the Treatment of Hirsutism The Journal of Clinical Endocrinology & Metabolism · 1995
- Leuprolide and Estrogen Versus Oral Contraceptive Pills for the Treatment of Hirsutism: A Prospective Randomized Study The Journal of Clinical Endocrinology & Metabolism · 1995
- Electrolysis: Observations from 13 Years and 140,000 Hours of Experience Journal of the American Academy of Dermatology · 1995
- Clinical and Endocrine Effects of Finasteride, a 5α-Reductase Inhibitor, in Women with Idiopathic Hirsutism Fertility and Sterility · 1995
- A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women The Journal of Clinical Endocrinology and Metabolism · 1995
- A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women The Journal of Clinical Endocrinology and Metabolism · 1995
- Acceptability, Tolerance, and Quality of Life Impact of Cyproterone Acetate Treatment in Female Hirsutism: Comparison of Two Protocols with Oral or Transdermal Estradiol PubMed · 1994
- Treatment of moderate and severe hirsutism by gonadotropin-releasing hormone agonists in women with polycystic ovary syndrome and idiopathic hirsutism Fertility and Sterility · 1994
- Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial Fertility and Sterility · 1994
- Cyproterone Acetate for Severe Hirsutism: Results of a Double-Blind Dose-Ranging Study Clinical endocrinology · 1991
- Comparison of Sequential Cyproterone Acetate/Estrogen Versus Spironolactone/Oral Contraceptive in the Treatment of Hirsutism The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1991
- Hirsutography: Photographic Measurement of Linear Hair Growth in Hirsute Women During Comparison of Anti-Androgen Treatments Journal of obstetrics and gynaecology · 1991
- Effect of Leuprolide and Dexamethasone on Hair Growth and Hormone Levels in Hirsute Women: The Relative Importance of the Ovary and the Adrenal in the Pathogenesis of Hirsutism The Journal of Clinical Endocrinology & Metabolism · 1990
- Lack of Effect of Spironolactone on Hair Shaft Diameter in Hirsute Females Postgraduate medical journal · 1989
- Treatment of Hirsutism With Cimetidine: A Prospective Randomized Controlled Trial Fertility and sterility · 1989
- A Comparative Study of Aldactone and Diane in the Treatment of Hirsutism Journal of steroid biochemistry/Journal of Steroid Biochemistry · 1987
- Cyproterone Acetate as Initial Treatment and Maintenance Therapy for Hirsutism European journal of endocrinology · 1985
- THE TREATMENT OF HIRSUTISM: EXPERIENCE WITH CYPROTERONE ACETATE AND SPIRONOLACTONE Australasian Journal of Dermatology · 1985
- The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women Fertility and sterility · 1985
- Effects of a Low-Dose Desogestrel-Ethinylestradiol Combination on Hirsutism, Androgens, and Sex Hormone Binding Globulin in Women with Polycystic Ovary Syndrome Acta obstetricia et gynecologica Scandinavica · 1985
- The Effects of Benzodiazepines on Hormones in Women with Idiopathic Hirsutism Progress in neuro-psychopharmacology & biological psychiatry · 1984
- The Development and Evaluation of an Ovulation Inhibitor (Diane) Containing an Antiandrogen Acta obstetricia et gynecologica Scandinavica · 1979
- An Assessment of Cyproterone Acetate and Ethinyl Estradiol and Lynoestrenol (Minilyn) in the Treatment of Idiopathic Hirsutism British journal of dermatology/British journal of dermatology, Supplement · 1978
- Treatment of Hirsutism and Acne in Women With Two Combinations of Cyproterone Acetate and Ethinylestradiol PubMed · 1976