Therapy of Endocrine Disease: Treatment of Hirsutism in Polycystic Ovary Syndrome

The document discusses the treatment of hirsutism, particularly in women with polycystic ovary syndrome (PCOS). Hirsutism, characterized by excessive hair growth, is linked to increased androgen production and availability, with some androgens being produced directly in the hair follicle. The decision to treat hirsutism should be based on both the severity of the condition and the patient's subjective distress, rather than solely on objective hair growth. Treatment options include cosmetic procedures and pharmacological interventions, which should be chosen after diagnosing the underlying cause and explaining the potential efficacy of each option to the patient. The paper emphasizes that treatment should be tailored to the individual, noting that women with PCOS and hirsutism may present different phenotypes, and that lifestyle interventions should be considered, especially in the presence of obesity, potentially in combination with pharmacotherapy.