Cyproterone Acetate for Hirsutism

    October 2003 in “ Cochrane library ”
    Zephne M van der Spuy, Paul A. le Roux, Mushi Matjila
    TLDR Cyproterone acetate with estradiol may subjectively improve excessive hair growth in women, but it's not clinically better than other treatments.
    The review investigated the effectiveness of cyproterone acetate, alone or with ethinyl estradiol, in treating hirsutism in women due to ovarian hyperandrogenism. Nine randomized studies were included, with only one having over 100 participants. The review found that cyproterone acetate combined with ethinyl estradiol significantly reduced hair growth compared to placebo, though the confidence limits were large. No significant clinical differences were noted when comparing cyproterone acetate to other drugs like ketoconazole and spironolactone. The studies were too small and lacked standardized assessments to draw definitive conclusions. Larger, well-designed studies are needed to better compare the efficacy and safety of treatments for hirsutism. Cyproterone acetate appeared as effective as other medications, but there was insufficient data to compare side effects.
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