Acceptability, Tolerance, and Quality of Life Impact of Cyproterone Acetate Treatment in Female Hirsutism: Comparison of Two Protocols with Oral or Transdermal Estradiol

    December 1994 in “ PubMed ”
    Sergio Consoli, P. Vexiau, Consoli Sg, Y Abramovici
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    TLDR Cyproterone acetate with estradiol improved women's self-confidence and emotional well-being without a difference between oral or transdermal methods, but younger women preferred the oral method.
    In a study conducted 29 years ago, 67 women aged 16-40 with hirsutism and/or other signs of hyperandrogenism (acne, androgenic alopecia, cycle disturbances) were treated for one year with cyproterone acetate + estradiol. The patients were randomly assigned to therapy with cyproterone acetate and estradiol valerate per or cyproterone acetate and transdermal estradiol. The treatment resulted in a significant improvement in acceptance of being exposed to view (p < 0.01), self-assurance (p < 0.01) as well as emotional well-being score (p < 0.05), without any significant difference between the two therapeutic groups. Compliance of treatment with transdermal estradiol was found to be lesser in younger patients but better in patients in whom emotional balance was improved by therapy.
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