Anti-Androgens in Gynecological Practice

    September 1988 in “ Baillière's clinical obstetrics and gynaecology ”
    Michael J. Reed, Stephen Franks
    TLDR Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.
    Hirsutism and acne in women were common issues caused by androgens affecting the skin, influenced by androgen production and bioavailability. Effective anti-androgens blocked androgen receptor-mediated actions of testosterone and DHT. Cyproterone acetate (CPA) was the preferred treatment in the UK, acting as a potent androgen receptor blocker with progestational properties. When combined with ethinyloestradiol, CPA also suppressed ovarian function, reducing androgen production and providing effective contraception.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 29 results

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  53 upvotes 2 years ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  34 upvotes 6 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community Spironolactone or bicalutamide prescription

      in Treatment  4 upvotes 2 years ago
      The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

    Similar Research

    6 / 1000+ results
      Sexual Hormones in Human Skin

      research Sexual Hormones in Human Skin

      305 citations , February 2007 in “Hormone and metabolic research”
      Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.
      Diagnosis of Hyperandrogenism: Biochemical Criteria

      research Diagnosis of Hyperandrogenism: Biochemical Criteria

      77 citations , June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism”
      The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.
      Acne Vulgaris

      research Acne Vulgaris

      January 2018 in “Springer eBooks”
      The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.
      Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

      research Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

      November 2020 in “Elsevier eBooks”
      Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.