Anti-Androgens in Gynecological Practice

    September 1988 in “ Baillière's clinical obstetrics and gynaecology ”
    Michael J. Reed, Stephen Franks
    TLDR Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.
    Hirsutism and acne in women were common issues caused by androgens affecting the skin, influenced by androgen production and bioavailability. Effective anti-androgens blocked androgen receptor-mediated actions of testosterone and DHT. Cyproterone acetate (CPA) was the preferred treatment in the UK, acting as a potent androgen receptor blocker with progestational properties. When combined with ethinyloestradiol, CPA also suppressed ovarian function, reducing androgen production and providing effective contraception.
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