The Effect of Anti-Androgens on the Response of Rat Preputial Glands to Testosterone

September 1964 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

E. Linn Jones, Linda P. Woodbury

anti-androgens testosterone androgens prostate cancer acne vulgaris hirsutism male pattern baldness anti-androgens testosterone androgens prostate cancer acne excessive hair growth hair loss

TLDR New compounds can block testosterone effects in rats and might help treat conditions like prostate cancer and acne.

The document discusses the discovery of new compounds with anti-androgenic effects that counteract the influence of testosterone in experimental animals without significant estrogenic effects. These compounds are considered potentially useful for treating diseases thought to be exacerbated by androgens, including prostate cancer, acne vulgaris, hirsutism, and male pattern baldness. The research is focused on the response of rat preputial glands to testosterone and the impact of anti-androgens on this response.

View this study on jidonline.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations, December 2011 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

research An Update on Plant-Derived Anti-Androgens

38 citations, July 2012 in “international journal of endocrinology and metabolism”

Some plant-derived compounds may help with hormonal conditions, but more research is needed to confirm their effectiveness.

research Skin Steroidogenesis in Health and Disease

47 citations, September 2016 in “Reviews in endocrine and metabolic disorders”

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

research Hormonal Therapies for Acne

26 citations, October 2016 in “Clinics in Dermatology”

Hormonal treatments can improve acne, but they come with potential side effects and risks.

research Adrenal Steroid Precursors Exert Potent Androgenic Action in the Hamster Sebaceous Glands of Flank Organs and Ears

8 citations, May 1996 in “Endocrinology”

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

The Effect of Anti-Androgens on the Response of Rat Preputial Glands to Testosterone

Related Community Posts Join

community Derm prescribed ketoconazole 2% shampoo, claiming my case “is not bad enough yet” for fin. Second opinion?

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

community So we’re just ok with taking a research chemical now?

community The truth about Dutasteride (w/ sources)