A Comparative Study of Aldactone and Diane in the Treatment of Hirsutism

    August 1987 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    O. C. Lunde, O. Djøseland
    Image of study
    TLDR Aldactone was more effective in reducing hair growth in women with hirsutism than Diane, despite having less impact on hormone levels.
    In a study from 1987 involving 36 women, Aldactone® (50 mg per day) was compared to Diane® for the treatment of hirsutism. The study found that while Aldactone had little effect on hormone concentrations except for a significant reduction in LH after 12 months, all 14 women treated with it reported reduced hair growth, and 58% noted a decrease in new hair growth after 5 months. In contrast, Diane led to a marked decrease in hormone levels and affected hair parameters, but the clinical effects were not as pronounced as with Aldactone, with about 20% of the 22 women showing no response in hair growth reduction, new hair formation, or hair softening. Additionally, the response time was longer with Diane than with Aldactone. The results suggest that Aldactone may have a better clinical effect on hair parameters at the dosages used, despite its minimal hormonal effects. However, it was noted that Diane contains only 2 mg of cyproterone acetate (CPA), and a higher dosage might yield better results.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 7 results

    Similar Research

    5 / 179 results
      Medical Treatment Regimens of Hirsutism

      research Medical Treatment Regimens of Hirsutism

      12 citations, January 2004 in “Reproductive biomedicine online”
      Low-dose anti-androgen drugs and certain drug combinations are effective for hirsutism, and insulin sensitizers show promise, especially for those with polycystic ovarian syndrome.
      Clinical Applications of Antiandrogens

      research Clinical Applications of Antiandrogens

      29 citations, October 1988 in “Journal of Steroid Biochemistry”
      Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.
      Treatment of Hyperandrogenism in Women

      research Treatment of Hyperandrogenism in Women

      8 citations, January 1996 in “Gynecological Endocrinology”
      Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.
      The Evaluation and Management of Hirsutism

      research The Evaluation and Management of Hirsutism

      195 citations, May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”
      Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.
      The Evaluation and Management of Hirsutism

      research The Evaluation and Management of Hirsutism

      11 citations, May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”
      Hirsutism in women often indicates a hormonal imbalance and can be managed with a combination of hormonal treatments and hair removal methods.