Clinical applications of antiandrogens

The document from 1988 detailed the use of antiandrogens in treating various conditions related to androgen activity, such as prostate cancer, benign prostatic hypertrophy, skin issues like hirsutism, alopecia, and acne, as well as other conditions like early puberty and sexual deviations. It discussed the effectiveness of steroidal and non-steroidal antiandrogens, particularly cyproterone acetate, flutamide, and anandron, highlighting their use alone or in combination with treatments like castration or LH-RH analogs. Studies mentioned include one with 55 prostate cancer patients showing a 64% response rate to antiandrogens and another with 236 patients indicating good survival rates. Side effects were noted, such as visual impairment with anandron, and the need for larger randomized trials was emphasized, especially for confirming the utility of antiandrogens in treating benign prostatic hyperplasia and dermatologic conditions. The document also pointed out the potential of topical antiandrogens to minimize side effects and the effectiveness of cyproterone acetate in various conditions, but again noted the necessity for larger studies to confirm these findings.