New Therapeutic Approach to the Hirsute Patient
September 1979
in “
Fertility and sterility
”
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Studysummary This study found that spironolactone reduced testosterone production and urinary 17-ketosteroid excretion, leading to a decrease in hair growth rate and a change in hair texture in women.
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The study investigated spironolactone's effectiveness in treating hirsutism in women by administering it to 10 healthy women and 6 hirsute women. Results showed a significant reduction in testosterone production and urinary 17-ketosteroid excretion. After 6 months, hirsute patients experienced decreased hair growth rate and finer hair. The study concluded that spironolactone's antiandrogenic effects were due to reduced testosterone production and competitive inhibition at androgen receptors in hair follicles, suggesting it could be a beneficial treatment for hirsutism.
