Long-Term Satisfaction and Tolerability with Low-Dose Flutamide: A 20-Year Surveillance Study on 120 Hyperandrogenic Women

May 2016 in “ Gynecological Endocrinology ”

Camil Castelo-Branco, Claudio Hernández-Angeles, Lina Alvarez-Olivares, Juan Balasch

flutamide hirsutism hyperandrogenic dry skin hypertransaminasemia acute fatty liver

Studysummary This study found that while flutamide was very effective in improving hirsutism in women over long-term treatment, a high incidence of adverse effects led to a majority discontinuing the therapy.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study assessed the long-term effects of low-dose flutamide on 120 hyperandrogenic women over 20 years, finding significant improvements in hirsutism with a high patient satisfaction rate. Over 91% of participants reported satisfaction, and hirsutism scores were nearly halved after 12 months of treatment. However, 54.2% experienced adverse effects, with 33.3% possibly related to flutamide, leading to a 24.1% withdrawal rate. Common side effects included dry skin, abdominal pain, flatulence, and nausea, with 11 cases of mild hypertransaminasemia and one case of acute fatty liver. Despite the high efficacy, the study emphasized the need for careful consideration of flutamide use due to the common occurrence of adverse effects.

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Research cited in this study

8 / 8 results

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