Biological Activity of Antiandrogens

June 1970 in “ British journal of dermatology/British journal of dermatology, Supplement ”

Ralph I. Dorfman

antiandrogens androgens hirsutism androgen-dependent prostatic tumors benign prostatic hypertrophy hypertrichosis male baldness facial hair growth acne bioassay models human skin prostate cancer BPH excessive hair growth hair loss skin testing

TLDR Antiandrogens may help treat conditions like excessive hair growth, prostate tumors, male baldness, and acne by blocking male hormone effects.

The document discusses antiandrogens, which are substances that block the effects of androgens at their target sites, differentiating them from compounds that reduce hormone synthesis or release, or those that act directly on the gonads. Antiandrogens have both practical and theoretical significance, with potential benefits for women with certain types of hirsutism and men with androgen-dependent prostatic tumors or benign prostatic hypertrophy. They could also be used locally to treat hypertrichosis in women, prevent some types of male baldness, inhibit facial hair growth in men, and treat or prevent acne in both young men and women. The focus of the communication is on the biological activity of antiandrogens, especially regarding bioassay models that can predict their therapeutic effectiveness on human skin.

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