Treatment of Androgen Excess in Females: Yesterday, Today, and Tomorrow

    January 1997 in “ Gynecological Endocrinology ”
    Enrico Pucci, Felice Petraglia
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    TLDR The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.
    The 1997 document reviews treatments for androgen excess in females, addressing conditions like hirsutism, acne, and androgenic alopecia. It emphasizes the psychological impact of these conditions and the need to rule out serious underlying issues. Treatment strategies include surgery, glucocorticoids, gonadotropin secretion inhibitors, and androgen receptor blockers, with potential future treatments like somatostatin analogs. The document details various pharmacological options, such as GnRH antagonists, estrogens, progestogens, oral contraceptives, adrenal suppressants, anti-prolactinemic drugs, and antiandrogens like cyproterone acetate and spironolactone, discussing their efficacy, side effects, and specific uses. It also mentions non-pharmacological approaches like weight reduction and cosmetic measures. The paper concludes that treatment requires patience, managing patient expectations is crucial, and that many drugs used for hyperandrogenism are not officially licensed for this purpose, suggesting cosmetic treatments as an alternative for milder cases.
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