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GlossaryGonadotropin-Releasing Hormone Antagonists (GnRH antagonists)

medications that block hormone signals to reduce sex hormone production

Gonadotropin-Releasing Hormone Antagonists (GnRH antagonists) are medications that block the action of GnRH, a hormone responsible for stimulating the release of other hormones like LH and FSH from the pituitary gland. By inhibiting this pathway, GnRH antagonists can reduce the production of sex hormones such as testosterone and estrogen, making them useful in treatments for conditions like prostate cancer, endometriosis, and certain fertility issues.

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research Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline

855 citations, June 2009 in “The Journal of Clinical Endocrinology & Metabolism”

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

research Gender-Affirming Hormone Therapy for Transgender Females

32 citations, September 2018 in “Clinical Obstetrics and Gynecology”

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

research Treatment Options for Polycystic Ovary Syndrome

514 citations, February 2011 in “International journal of women's health”

Different treatments for PCOS focus on the specific symptoms, with weight loss and lifestyle changes being important.

research Hirsutism II: Treatment

15 citations, August 1998 in “Australasian journal of dermatology”

The document concludes that various cosmetic and drug treatments are available for hirsutism, and some new drugs show promise.

research Infertility Treatment in Polycystic Ovary Syndrome: Lifestyle Interventions, Medications, and Surgery

19 citations, October 2012 in “Frontiers of Hormone Research”

Lifestyle changes are the first step in treating infertility in PCOS, followed by medications like clomiphene and metformin, and then surgery if needed.

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community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

Thelondonvoyager in Finasteride/Dutasteride 113 upvotes 2 years ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

BanksCarlton in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.

levi_io in Transgender 125 upvotes 1 year ago

A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.

community Insane MTF recovery 18 months blocking androgens

Mindless-Ad-7102 in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

nottimber in Finasteride 80 upvotes 5 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.