Comparative Management Methods for Adolescents With Polycystic Ovarian Syndrome: A Systematic Review

    March 2024 in “ Curēus ”
    Roxana Vădan, Nelson Varela, Nikita Zhuravko, Noreena O Ogidan, Victor O Adedara, Emmanuel Keku
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    TLDR Individualized treatment plans, including lifestyle changes and specific medications, are crucial for managing PCOS in adolescents.
    This review examines various management methods for adolescents with polycystic ovarian syndrome (PCOS), highlighting the importance of individualized treatment plans. Lifestyle modifications, such as vigorous exercise and low-carbohydrate diets, are the most preferred methods for symptom reduction. Pharmaceuticals like metformin, oral contraceptives, GnRH antagonists, finasteride, eflornithine, FGFs, and vitamin D show promise in improving insulin sensitivity, regulating menstrual cycles, and reducing hirsutism. Epilatory and surgical options are considered only when other treatments fail and the patient reaches an appropriate age. The review emphasizes the need for personalized pharmacotherapy based on each adolescent's unique symptoms.
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