Dutasteride Isn't Working? Get a Scalp Biopsy NOW
    Finasteride/Dutasteride 2/13/2025

    From the encyclopedia
    Dutasteride →

    Heavy duty finasteride that comes with higher risks

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Pyrilutamide →

    highly targeted anti-androgen that might have minimal systemic effects

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💊 Dutasteride (oral) 0.5mg or 2.5mg
    💧 Minoxidil (topical)
    💧 Pyrilutamide (topical) 20 mg
    the tone is 😐 neutral.

    Other terms

    Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.
    View this post in the Community →

    Similar Community Posts Join

    5 / 5 results

      community If after 3 years nothing works should i get scalp biopsy

      in Treatment  7 upvotes 1 year ago
      The user has tried various treatments like Dutasteride, RU58841, Minoxidil, Finasteride, Spironolactone, Pyrilutamide, and Ketoconazole for hair loss without success and is considering a scalp biopsy to diagnose another condition. Others suggest consulting a dermatologist and possibly getting a biopsy, as the issue might not be typical male pattern baldness.

      community Scalp Biopsy Results - Almost 2 Years Dutasteride, Still Worsening

      in Update  24 upvotes 1 year ago
      Dutasteride and finasteride are not effectively stopping hair loss for some users, despite long-term use. Some are considering or using RU58841, pyrilutamide, and other treatments like microneedling, while also managing seborrheic dermatitis with diet and topical solutions.

      community On Dutasteride 0.5mg ED for almost 2 years. Increasingly shedding hair for more than 5 months.

      in Finasteride/Dutasteride  7 upvotes 1 year ago
      The user experienced increased hair shedding after switching from finasteride to dutasteride, despite lifestyle improvements and additional treatments like oral minoxidil and PRP. They are concerned about persistent shedding, changes in hormone levels, and potential chronic telogen effluvium, and are considering a scalp biopsy for further investigation.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 4 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

    Related Research

    6 / 6 results
      Recent Advances in Drug Development for Hair Loss

      research Recent Advances in Drug Development for Hair Loss

      April 2025 in “International Journal of Molecular Sciences”
      This review highlights the limitations of existing hair loss treatments like minoxidil and finasteride and suggests that future therapies may benefit from focusing on antibody and cell-based treatments, which offer targeted and potentially transformative options for managing hair loss disorders.
      Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives

      research Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives

      June 2025 in “Journal of Cluster Science”
      This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.
      Hair Loss in Women: Comprehensive Overview and Treatment Options

      research Hair Loss in Women

      81 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”
      This review discusses the classifications, diagnostic methods, and treatment strategies for female pattern hair loss, but reports no clinical results.
      Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments

      research Pattern Hair Loss in Men

      58 citations , September 2012 in “Dermatologic Clinics”
      This article reviews current knowledge on the causes, diagnosis, and medical treatments for androgenetic alopecia, particularly in men, and reports no new findings.
      Management of Hair Loss Diseases

      research Management of hair loss diseases

      14 citations , December 2010 in “Dermatologica Sinica”
      This article reviews recent advances and therapeutic approaches in treating alopecia areata, highlighting new potential treatments like pulse corticosteroid therapy, but reports no new research findings.

      research Androgenic alopecia and differential diagnoses of alopecia

      October 2023 in “University of Zadar Institutional Repository”
      This paper describes androgenic alopecia as a hereditary form of hair loss influenced by androgens, outlining its diagnosis, treatment options like minoxidil and finasteride, and the importance of psychological support due to its impact on quality of life.