Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives

    June 2025 in “ Journal of Cluster Science ”
    Rahul Pokale, Anoushka Mukharya, Amrita Arup Roy … Srinivas Mutalik
    Studysummary This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 81

    1. Hybrid Hair Follicle Stem Cell Extracellular Vesicles Co-Delivering Finasteride and Gold Nanoparticles for Androgenetic Alopecia Treatment Journal of Controlled Release · 2024
    2. Traditional Scraping Combined with Copper-Curcumin Nanoparticle Oleogel for Therapy of Androgenic Alopecia Advanced Healthcare Materials · 2024
    3. Molybdenum Nanoparticles as a Potential Topical Medication for Alopecia Treatment Journal of Trace Elements in Medicine and Biology · 2023
    4. Nanotechnology-Based Techniques for Hair Follicle Regeneration Biomaterials · 2023
    5. Mesenchymal Stromal Cell-Derived Magnetic Nanovesicles for Enhanced Skin Retention and Hair Follicle Growth Cytotherapy · 2023
    6. 3D Bioprinting of Calcium Molybdate Nanoparticles-Containing Immunomodulatory Bioinks for Hair Regrowth Nano today · 2023
    7. Curcumin-Zinc Framework Encapsulated Microneedle Patch for Promoting Hair Growth Theranostics · 2023
    8. A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch Bioactive Materials · 2022
    9. Green Synthesis of Zinc Oxide Nanoparticles Using Monotheca Buxifolia Leaf Extract; Their Biological Activities and Use in Fabrication of Nano-Biosensor Surface Engineering and Applied Electrochemistry · 2022
    10. Platelet Rich Plasma and Its Use in Hair Regrowth: A Review Drug design, development and therapy · 2022
    11. Fabrication of Silver Nanoparticles from Ziziphus Nummularia Fruit Extract: Effect on Hair Growth Rate and Activity Against Selected Bacterial and Fungal Strains Journal of nanomaterials · 2022
    12. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    13. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    14. Curcumin/Fe-SiO2 Nano Composites with Multi-Synergistic Effects for Scar Inhibition and Hair Follicle Regeneration During Burn Wound Healing Applied Materials Today · 2021
    15. Hair Transplantation: Basic Overview Journal of The American Academy of Dermatology · 2021
    16. Alopecia Types, Current and Future Treatment Journal of dermatology & cosmetology · 2021
    17. Green Synthesis of Silver Nanoparticles Using Grewia Optiva Leaf Aqueous Extract and Isolated Compounds as Reducing Agent and Their Biological Activities Journal of nanomaterials · 2020
    18. In Vivo and In Vitro Hair Growth-Promoting Effect of Silver and Iron Nanoparticles Synthesized via Blumea Eriantha DC Plant Extract Journal of Cosmetic Dermatology · 2020
    19. Efficacy and Safety of Oral Minoxidil in Female Androgenetic Alopecia Dermatologic Therapy · 2020
    20. Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia International Journal of Pharmaceutics · 2020
    21. MoS2 Nanoclusters-Based Biomaterials for Disease-Impaired Wound Therapy Applied Materials Today · 2020
    22. Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment Polymers · 2020
    23. Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients Dermatology practical & conceptual · 2020
    24. Safety of Oral Bicalutamide in Female Pattern Hair Loss: A Retrospective Review of 316 Patients Journal of The American Academy of Dermatology · 2020
    25. Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin ACS Applied Materials & Interfaces · 2020
    26. A Hair-Raising History of Alopecia Areata Experimental Dermatology · 2020
    27. Alopecia Areata and Toxic Metals Skin appendage disorders · 2020
    28. A Summary of In Vitro, Phase I, and Phase II Studies Evaluating the Mechanism of Action, Safety, and Efficacy of Clascoterone (Cortexolone 17a Propionate, CB-03-01) in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2019
    29. An Overview of Herbal Alternatives in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    30. Braids or Ponytail-Associated Traction Alopecia in Female Children Annals of dermatology/Annals of Dermatology · 2019
    31. Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study Skin appendage disorders · 2019
    32. Multifunctional Zinc-Doped Hollow Mesoporous Silica/Polycaprolactone Electrospun Membranes with Enhanced Hair Follicle Regeneration and Antibacterial Activity for Wound Healing Nanoscale · 2019
    33. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    34. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    35. Tight Junction Barriers in Human Hair Follicles – Role of Claudin-1 Scientific reports · 2018
    36. Traction Alopecia: The Root of the Problem Clinical, cosmetic and investigational dermatology · 2018
    37. Morphological Studies of Penetration Pathways via Stratum Corneum and Hair Follicles Using Nano-Sized Iron Oxide Microscopy and Microanalysis · 2017
    38. Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature Skin appendage disorders · 2017
    39. Cutaneously Applied Nano-ZnO Reduces the Ability of Hair Follicle Stem Cells to Differentiate Nanotoxicology · 2017
    40. Frequency, Severity, and Related Factors of Androgenetic Alopecia in Dermatology Outpatient Clinic: Hospital-Based Cross-Sectional Study in Turkey Anais Brasileiros De Dermatologia · 2017
    41. In Vitro and In Vivo Evaluation of Biologically Synthesized Silver Nanoparticles for Topical Applications: Effect of Surface Coating and Loading into Hydrogels International journal of nanomedicine · 2017
    42. Gold Thread Implantation Promotes Hair Growth in Humans and Mice Laboratory Animal Research · 2017
    43. Trichotillomania: Differences From OCD and Treatment Approaches American Journal of Psychiatry · 2016
    44. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    45. Triggered Release of Model Drug from Gold Nanoparticle-Doped Bovine Serum Albumin Nanocarriers in Hair Follicles Using Infrared A Radiation Acta Biomaterialia · 2015
    46. Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model Journal of Ginseng Research · 2015
    47. Evaluation of Serum Zinc Level in Patients With Newly Diagnosed and Resistant Alopecia Areata International Journal of Dermatology · 2015
    48. Folliculitis Decalvans: A Multicenter Review of 82 Patients Journal of the European Academy of Dermatology and Venereology · 2015
    49. Prevalence and Factors Associated with Telogen Effluvium in Adult Females at Makkah Region, Saudi Arabia: A Retrospective Study Journal of Dermatology and Dermatologic Surgery · 2015
    50. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    51. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    52. Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients Journal of The American Academy of Dermatology · 2014
    53. Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study American Journal of Clinical Dermatology · 2014
    54. Beyond Goosebumps: Does the Arrector Pili Muscle Have a Role in Hair Loss? International Journal of Trichology · 2014
    55. Low-Level Laser Therapy for Treatment of Hair Loss Lasers in Surgery and Medicine · 2013
    56. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    57. Anagen Effluvium: A Review of Rapid Hair Loss During Growth Phase and Loose Anagen Hair Syndrome Indian Journal of Dermatology, Venereology and Leprology · 2013
    58. Analysis of Serum Zinc and Copper Concentrations in Hair Loss Annals of Dermatology · 2013
    59. Androgenetic Alopecia: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    60. Nutrition and Hair: The Role of Nutrients in Hair Health Dermatologic Clinics · 2012
    61. Hair: What Is New in Diagnosis and Management? Dermatologic Clinics · 2012
    62. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    63. Alopecia Areata: A New Treatment Plan Clinical, cosmetic and investigational dermatology · 2011
    64. Treatment of Chemotherapy-Induced Alopecia Dermatologic Therapy · 2011
    65. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    66. Hair Growth and Rejuvenation: An Overview Journal of Dermatological Treatment · 2010
    67. Temporal Triangular Alopecia and a Review of 52 Past Cases Journal of Dermatology · 2010
    68. Diffuse Hair Loss in an Adult Female: Approach to Diagnosis and Management Indian Journal of Dermatology, Venereology and Leprology · 2009
    69. Hair Growth Stimulatory Effect by a Combination of 5-Aminolevulinic Acid and Iron Ion International Journal of Dermatology · 2008
    70. Prevention of Chemotherapy-Induced Alopecia in Rodent Models Cell stress & chaperones · 2008
    71. Imaging of Zinc Oxide Nanoparticle Penetration in Human Skin In Vitro and In Vivo Journal of biomedical optics · 2008
    72. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    73. Diffuse Alopecia in a Child Due to Dietary Zinc Deficiency SKINmed Dermatology for the Clinician · 2007
    74. The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro Archives of Pharmacal Research · 2007
    75. The Diagnosis and Treatment of Iron Deficiency and Its Potential Relationship to Hair Loss Journal of The American Academy of Dermatology · 2006
    76. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    77. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    78. Decreased Serum Ferritin Is Associated With Alopecia in Women Journal of Investigative Dermatology · 2003
    79. Treatment of Hyperandrogenic Alopecia in Women Fertility and Sterility · 2003
    80. Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    81. The Effect of Cyproterone Acetate on Hair Roots and Hair Shaft Diameter in Androgenetic Alopecia in Females Springer eBooks · 1989