Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment

June 2020 in “ Polymers ”

Jen-Hung Fang, Che-Hau Liu, Ru-Siou Hsu, Yinyu Chen, Wen-Hsuan Chiang, Huimin Wang, Shang-Hsiu Hu

transdermal composite microneedle mesoporous iron oxide nanoraspberry polyvinyl alcohol androgenetic alopecia stratum corneum hair re-growth MNs MIO PVA AGA

Studysummary This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study developed a transdermal composite microneedle (MNs) for the treatment of androgenetic alopecia (AGA). The MNs were composed of mesoporous iron oxide nanoraspberry (MIO) and polyvinyl alcohol (PVA). The MNs were able to break through the stratum corneum barrier and dissolve in the skin, making them a potential delivery system for drugs. In vivo animal hair growth experiments on mice showed that the mice treated with Mx-MIOs@MNs demonstrated 25% and 40% of hair re-growth at the 3rd and 7th days of treatment, respectively, while no hair was found regrowth beyond the treated region. The study concluded that the developed MNs showed potential for the treatment of androgenetic alopecia.

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