The Effect of Lactobacillus Plantarum Hydrolysates Promoting VEGF Production on Vascular and Hair Growth in C57BL/6 Mice

The study conducted by Woo et al. focused on the effects of Lactobacillus plantarum hydrolysates on hair growth in C57BL/6 mice, specifically looking at the production of vascular endothelial growth factor (VEGF) and its influence on hair growth. The hydrolysates, created by hydrolyzing L. plantarum with proteases, were applied to human dermal papilla cells to examine the relationship between cell growth and VEGF secretion. The findings indicated that the hydrolysates, particularly those treated with the protease Protamex (LP-P group), significantly increased IGF-1 concentrations and stimulated hair growth more effectively than 5% minoxidil. The LP-P group also showed rapid hair growth by day 8 and increased VEGF secretion, suggesting that L. plantarum hydrolysates could be potential ingredients for cosmetic, health food, and medicinal products aimed at promoting hair growth. However, the exact number of mice used in the experiments was not provided in the summary.