Lactobacillus Paracasei HY7015 and Lycopus Lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

November 2022 in “ Molecules/Molecules online/Molecules annual ”

Hayera Lee, Hyeonji Kim, Ji Hyun Kim, Soo-Dong Park, Jae-Jung Shim, Jeong-Lyoul Lee

Lactobacillus paracasei HY7015 Lycopus lucidus Turcz. extract hair regrowth hair follicle formation VEGF IGF-1 SOD1 IL-1β oxidative stress rosmarinic acid LT extract vascular endothelial growth factor insulin-like growth factor 1 superoxide dismutase 1 interleukin 1 beta

Studysummary This study found that ingesting Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. extract promoted hair regrowth and follicle maturation in mice by enhancing cytoprotective effects and growth factor expression.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

25 / 25 results

research Lactobacillus Paracasei HY7015 Promotes Hair Growth in a Telogenic Mouse Model

9 citations , July 2021 in “Journal of Medicinal Food”

This study found that consuming Lactobacillus paracasei HY7015 promoted hair growth and follicle maturation in mice, likely through stimulating dermal papilla cell proliferation and growth factor secretion.

research Hair Growth Potential of Salvia Plebeia Extract and Its Associated Mechanisms

21 citations , January 2020 in “Pharmaceutical Biology”

In this study, Salvia plebeia extract promoted hair growth by enhancing proliferation and anti-apoptotic effects in human dermal papilla cells and increased hair growth in treated mice.

research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

35 citations , January 2020 in “Skin Pharmacology and Physiology”

This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.

research The Effect of Lactobacillus Plantarum Hydrolysates Promoting VEGF Production on Vascular and Hair Growth in C57BL/6 Mice

10 citations , April 2019 in “Journal of Analytical Science and Technology”

In this study, hydrolysates of lactic acid bacteria were found to enhance hair growth in C57BL/6 male mice more effectively than 5% minoxidil.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.

research Mechanism of Action of Minoxidil in the Treatment of Androgenetic Alopecia Is Likely Mediated by Mitochondrial Adenosine Triphosphate Synthase-Induced Stem Cell Differentiation

6 citations , February 2018 in “PubMed”

This study suggests that minoxidil may promote hair growth in androgenetic alopecia by increasing intracellular calcium, which enhances stem cell differentiation, offering insights for new drug development.

research Scalp Condition Impacts Hair Growth And Retention Via Oxidative Stress

40 citations , January 2018 in “International journal of trichology”

This article reviews the relationship between scalp conditions and hair health, suggesting that shampoos with Malassezia inhibitory agents may help reduce premature hair loss, but it presents no new clinical results.

research A Novel Multi-Targeting Approach to Treating Hair Loss Using Standardized Nutraceuticals

20 citations , November 2017 in “PubMed”

This review discusses the potential benefits of a nutraceutical with biooptimized botanical extracts for treating hair loss and reports no new clinical results; ongoing studies aim to validate its efficacy.

research Expert System for Hair Loss Diagnosis and Treatment

72 citations , June 2017 in “Zenodo (CERN European Organization for Nuclear Research)”

This article reviews conventional and alternative treatments for hair loss, noting FDA-approved drugs like Minoxidil and Finasteride, but reports no new clinical findings; the authors highlight concerns about side effects, spurring interest in herbal remedies.

research The Impact of Oxidative Stress on Hair

59 citations , November 2015 in “International Journal of Cosmetic Science”

This review considers oxidative stress effects on hair aging and emphasizes the need for dermatologists to recognize and treat factors affecting scalp and hair health, but it provides no new clinical findings.

research Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-Beta Expression

27 citations , September 2015 in “Drug Design Development and Therapy”

This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.

research In Vivo Hair Growth Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid from Bacillus Subtilis (Chungkookjang)

9 citations , March 2015 in “Journal of Microbiology and Biotechnology”

This study found that ultra-high molecular weight poly-γ-glutamic acid promoted hair growth in telogenic C57BL/6 mice by inhibiting 5-alpha reductase activity and inducing the anagen phase.

research Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-β Expression.

26 citations , January 2015 in “PubMed”

This study found that the type IV collagenases, MMP-2 and MMP-9, play significant roles in the hair cycle, potentially through their influence on VEGF, IGF-1, and TGF-β expression.

research Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride

32 citations , January 2015 in “Indian Dermatology Online Journal”

This study found that a combination of topical minoxidil and finasteride helped maintain hair density in patients with androgenetic alopecia after initial oral finasteride treatment.

research Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that in mice, epidermal Wnt/β-catenin signaling influences adipocyte differentiation and hair growth, suggesting its critical role in synchronizing adipogenesis with the hair growth cycle.

research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia

28 citations , August 2011 in “Journal of The American Academy of Dermatology”

This study found that men with early-onset androgenetic alopecia had significantly larger prostate volumes and lower urinary flow rates compared to healthy controls, suggesting a possible link between AGA and prostate-related urinary symptoms.

research In Vitro and In Vivo Hair Growth Promotion Effects of Lactobacillus Plantarum-Fermented Plant Extracts (MBN)

12 citations , June 2011 in “Han-guk sikpum gwahakoeji/Han'gug sigpum gwahag hoeji/Han-guk sikpum gwahak hoeji”

This study found that MBN, an herbal extract fermented by Lactobacillus plantarum, promoted hair growth and increased related gene expression in C57BL/6 mice.

research The Promoting Effect of Pleuropterus Cilinervis Extracts Fermented with Lactobacillus Rhamnosus on Hair Growth

4 citations , January 2011

This study found that Pleuropterus cilinervis extracts and animal milk fermented with Lactobacillus rhamnosus promoted hair growth in mice, suggesting potential applications in hair loss treatments.

research Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey

69 citations , April 2010 in “British Journal of Dermatology”

This study found a significant association between androgenetic alopecia and metabolic syndrome, highlighting high-density lipoprotein cholesterol as a particularly important factor.

research Is There a Gut-Brain-Skin Axis?

185 citations , January 2010 in “Experimental Dermatology”

This study introduces the concept of a "gut–brain–skin axis" where ingesting a specific Lactobacillus strain in mice may reduce stress-induced skin inflammation and hair growth inhibition.

research Association of Androgenetic Alopecia and Hypertension

34 citations , August 2007 in “PubMed”

This study found a strong association between androgenetic alopecia and hypertension in Caucasian men, independent of age.

research Exogenous Factors in Hair Disorders

11 citations , January 2004 in “Exogenous dermatology”

This review discusses the impact of various external factors like cosmetics, traction, and radiation on hair health and color, but reports no new findings.

research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

71 citations , January 2004 in “Dermatology”

This study found that oral finasteride was more effective than 5% topical minoxidil in treating mild to severe androgenetic alopecia in males, with both treatments deemed effective and safe over 12 months.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

This study found that minoxidil significantly increases VEGF mRNA and protein expression in dermal papilla cells, suggesting a role in enhancing hair follicle vascularization in androgenetic alopecia.

research Hypertrichosis and Congenital Anomalies Associated With Maternal Use of Minoxidil

36 citations , March 1987 in “Pediatrics”

Minoxidil use during pregnancy can cause excessive hair growth and multiple birth defects in the baby.