Lactobacillus Paracasei HY7015 and Lycopus Lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

November 2022 in “ Molecules/Molecules online/Molecules annual ”

Hayera Lee, Hyeonji Kim, Ji Hyun Kim, Soo-Dong Park, Jae-Jung Shim, Jeong-Lyoul Lee

Lactobacillus paracasei HY7015 Lycopus lucidus Turcz. extract hair regrowth hair follicle formation VEGF IGF-1 SOD1 IL-1β oxidative stress rosmarinic acid LT extract vascular endothelial growth factor insulin-like growth factor 1 superoxide dismutase 1 interleukin 1 beta

TLDR The substances improved hair regrowth and protected hair cells in humans and mice.

The study concluded that Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. extract (LT) promote hair regrowth by enhancing hair follicle formation and increasing growth factors like VEGF and IGF-1 in C57BL/6 mice. These substances also exhibited cytoprotective effects by regulating SOD1 and IL-1β expressions under oxidative stress. The hair regrowth effect is attributed to the rosmarinic acid content in LT and the synergistic effects of HY7015. Further research is needed to understand the detailed mechanisms behind these effects.

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