Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-Beta Expression
September 2015
in “
Drug Design Development and Therapy
”
TLDR Collagenase IV is crucial for hair growth by affecting key growth factors.
The study explored the role of collagenase IV and the enzymes MMP-2 and MMP-9 in hair cycle regulation, revealing that their inhibition significantly reduced hair regrowth and follicle development in mice. These enzymes were crucial for promoting hair growth by inducing the expression of growth factors like VEGF, IGF-1, and TGF-β, which are essential for hair follicle development. The research suggested that MMP-2 and MMP-9 facilitated hair growth through angiogenesis and the release of growth factors, indicating potential therapeutic targets for hair loss treatment.
