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Glossary Collagenase

enzyme that degrades collagen in tissues

Collagenase is an enzyme that breaks down collagen, a key structural protein in the skin, bones, and connective tissues. This enzyme is crucial in processes like wound healing and tissue remodeling, as it helps to remove damaged collagen and make way for new tissue formation.

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Research

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research Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

27 citations , September 2015 in “Drug Design Development and Therapy”

This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.

research Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression.

26 citations , January 2015 in “PubMed”

This study found that the type IV collagenases, MMP-2 and MMP-9, play significant roles in the hair cycle, potentially through their influence on VEGF, IGF-1, and TGF-β expression.

research Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.

research Expression of the Orphan Protein Plet-1 during Trichilemmal Differentiation of Anagen Hair Follicles

30 citations , February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the orphan protein Plet-1 is expressed in specific keratinocytes of mouse hair follicles and may regulate keratinocyte interactions with inert tissues by affecting migration and adhesion.

research Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata

11 citations , December 1990 in “British Journal of Dermatology”

This study observed abnormal extracellular matrix patterns in hair follicles from alopecia areata patients, particularly in the dermal papilla of large anagen follicles and in catagen follicles from lesional sites.

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Community Join

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community 21M - 8 months on oral minoxidil, crown still thinning. Considering fin - thoughts?

in Finasteride/Dutasteride 9 upvotes 5 months ago

The conversation suggests starting finasteride or dutasteride alongside minoxidil for better hair loss treatment, as minoxidil alone is seen as ineffective without a DHT blocker. Some users also mention considering RU58841 as an alternative to finasteride.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

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