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GlossaryLysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

research Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

January 1989 in “Clinical and Experimental Dermatology”

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations , January 1987 in “Dermatology”

Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

research The Effect of the Drug Minoxidil on Hair Growth

3 citations , January 1988

Minoxidil helps hair grow, especially in people with mild hair loss.

research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts

20 citations , January 1994 in “Archives of Biochemistry and Biophysics”

Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.

Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

46 citations , December 1992 in “Journal of Investigative Dermatology”

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

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community So does oral minoxidil age your skin or not

in Minoxidil 41 upvotes 1 year ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

in Minoxidil 33 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 18 upvotes 1 year ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 9 upvotes 5 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community 137 years old and still far more hair than the average r/tressless user

in Satire 1071 upvotes 2 years ago

The post and conversation are about a user claiming to be 137 years old with a full head of hair. Specific treatments mentioned include dutasteride, RU58841, and minoxidil.

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