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    Glossary Lysyl Hydroxylase

    enzyme modifying lysine in collagen for tissue strength

    Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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    Research 30 of 188

    1. Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. Journal of Biological Chemistry · 1987 · 63 citations
    2. Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis Matrix Biology · 2005 · 38 citations
    3. Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note Journal of Pharmacology and Experimental Therapeutics · 2020 · 2 citations
    4. Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity KSBB Journal · 2012
    5. Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action Dermatology · 2009 · 37 citations
    6. Effects of Minoxidil on Cultured Human Skin Fibroblasts Dermatology · 1987 · 19 citations
    7. Inflammatory perifollicular fibrosis and alopecia International Journal of Dermatology · 1998 · 10 citations
    8. Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis Biomacromolecules · 2024 · 6 citations
    9. Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp Clinics in Dermatology · 1988 · 5 citations
    10. The Effect of the Drug Minoxidil on Hair Growth 1988 · 3 citations
    11. Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987 Clinical and Experimental Dermatology · 1989
    12. Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment. bioRxiv (Cold Spring Harbor Laboratory) · 2024
    13. Acne Scar Management: Minoxidil as a Promising Approach or a Mirage? International journal of biomedicine · 2023
    14. Chelators Depigment and Inorease Elasticity of Mink Skin Acta Agriculturae Scandinavica · 1987 · 2 citations
    15. Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells Archives of Biochemistry and Biophysics · 1994 · 33 citations
    16. Stimulation of elastin expression by minoxidil in chick skin fibroblasts Archives of Dermatological Research · 1995 · 15 citations
    17. Hormone replacement therapy and the skin Maturitas · 2000 · 138 citations
    18. Estrogens and the skin Climacteric · 2005 · 137 citations
    19. Oral Manifestations of Hematologic and Nutritional Diseases Otolaryngologic Clinics of North America · 2010 · 50 citations
    20. The effect of menopause on the skin and other connective tissues Gynecological Endocrinology · 2011 · 44 citations
    21. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016 · 42 citations
    22. Pseudoacromegaly induced by the long-term use of minoxidil Journal of The American Academy of Dermatology · 2003 · 41 citations
    23. ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 Frontiers in Physiology · 2018 · 17 citations
    24. Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model Tissue Engineering and Regenerative Medicine · 2024 · 9 citations
    25. Chapter 20. Pathogenesis and Treatment of Alopecias Annual Reports in Medicinal Chemistry · 1989 · 8 citations
    26. HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth Skin Pharmacology and Physiology · 2020 · 6 citations
    27. Spatiotemporal dynamics of mammalian wound healing Cell Discovery · 2026 · 4 citations
    28. Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection (Mesotherapy) for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-month Randomized Trial 2010 · 1 citations
    29. Perspectives on Dermatopathology Archives of Dermatology · 1976 · 1 citations
    30. Cosmeceuticals in Dermatology Springer eBooks · 2013 · 1 citations