Effects of Minoxidil on Cultured Human Skin Fibroblasts

January 1987 in “ Dermatology ”

Sheldon R. Pinnell, Sohail Murad

minoxidil lysyl hydroxylase collagen biosynthesis fibroblast proliferation connective tissue keloids hypertrophic scars scleroderma Rogaine

TLDR Minoxidil slows down skin cell growth and may help treat scars and skin conditions.

The study found that minoxidil inhibited lysyl hydroxylase activity in human skin fibroblasts, which is involved in collagen biosynthesis, without affecting prolyl hydroxylase activity. Minoxidil also inhibited fibroblast proliferation, but did not affect protein or RNA synthesis. The study suggests that minoxidil may be useful in controlling overgrowth of connective tissue and in managing conditions such as keloids, hypertrophic scars, and scleroderma.

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research Effects of Minoxidil on Cultured Human Skin Fibroblasts

19 citations, January 1987 in “Dermatology”

Minoxidil slows down skin cell growth and may help treat scars and skin conditions.