Effect of Minoxidil on Rabbit Lens Epithelial Cell Behavior In Vitro and In Situ

September 2001 in “ Graefes Archive for Clinical and Experimental Ophthalmology ”

Iku Ishida, Shizuya Saika, Yoshitaka Ohnishi

TLDR Minoxidil may help prevent capsular opacification after cataract surgery.

The study investigated the effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ. Minoxidil was found to potentially reduce capsular opacification after cataract surgery by reducing cell migration and proliferation. It did not harm rabbit lens epithelial cells up to a concentration of 3.0 mM, but it did decrease collagen production and inhibit cell proliferation. Minoxidil may have potential in preventing capsular opacification after cataract surgery. Further research is needed to develop effective delivery methods for using minoxidil as a treatment for posterior capsule opacification.

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Research cited in this study

2 / 2 results

Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

46 citations, December 1992 in “Journal of Investigative Dermatology”

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

63 citations, September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

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research Limitations of Human Occipital Scalp Hair Follicle Organ Culture for Studying the Effects of Minoxidil as a Hair Growth Enhancer

30 citations, September 2004 in “Experimental Dermatology”

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research Effect of Minoxidil on Rabbit Lens Epithelial Cell Behavior In Vitro and In Situ

21 citations, September 2001 in “Graefes Archive for Clinical and Experimental Ophthalmology”

Minoxidil may help prevent capsular opacification after cataract surgery.

research In Vitro Suppression of Human Lymphocyte Activity by Minoxidil

17 citations, January 1985 in “International Journal of Dermatology”

Minoxidil may help hair growth by stopping immune system attacks on hair follicles.

Effect of Minoxidil on Rabbit Lens Epithelial Cell Behavior In Vitro and In Situ

Research cited in this study

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

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