Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

December 1992 in “ Journal of Investigative Dermatology ”

Heather N. Yeowell, van 't Klooster Ha, Linda L. Walker, Saood Murad, Sheldon R. Pinnell

lysyl hydroxylase minoxidil hydralazine human skin fibroblasts prolyl hydroxylase cDNA mRNAs hair growth Rogaine

TLDR Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

This study from 30 years ago investigated the regulation of lysyl hydroxylase (LH) mRNAs in human skin fibroblasts by minoxidil derivatives and hydralazine. The researchers isolated a partial cDNA for LH and found that minoxidil decreased LH expression, while hydralazine had a paradoxical effect on prolyl and lysyl hydroxylase activities. The study provides insights into the regulation of LH and its potential role in hair growth.

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Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

Cited in this study

research Minoxidil Specifically Decreases the Expression of Lysine Hydroxylase in Cultured Human Skin Fibroblasts

research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

research Topical Minoxidil in Early Male Pattern Baldness