Minoxidil Specifically Decreases the Expression of Lysine Hydroxylase in Cultured Human Skin Fibroblasts

    April 1992 in “ Biochemical Journal
    Timo Hautala, Jukka Heikkinen, Kari I. Kivirikko, Risto Myllylä
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    TLDR Minoxidil reduces lysine hydroxylase in skin cells.
    Minoxidil, a drug used to treat hair loss, was found to specifically decrease the amount of lysine hydroxylase protein in cultured human skin fibroblasts. This decrease is due to a decrease in its synthesis at a pretranslational level, as minoxidil markedly decreases the amount of lysine hydroxylase mRNA. The decrease in the lysine hydroxylase mRNA appeared to be highly specific, as no changes were seen in the amounts of mRNAs for the a- or B-subunits of proline 4-hydroxylase or for y-actin.
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      community Minoxidil actually reduces wrinkles

      in Research/Science  209 upvotes 3 weeks ago
      Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

      community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

       128 upvotes 6 years ago
      Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

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