Minoxidil Cannot Be Used To Target Lysyl Hydroxylases During Postnatal Mouse Lung Development: A Cautionary Note

    Tilman Pfeffer, Ettore Lignelli, Hajime Inoue … Rory E. Morty
    Studysummary This study found that in a mouse model of bronchopulmonary dysplasia, minoxidil administered at 50 mg/kg/day did not impact lung development or inhibit lysyl hydroxylation.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jpet.aspetjournals.org →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Simultaneous Determination of Minoxidil and Minoxidil Sulfate by High-Performance Liquid Chromatography with UV Detection and Its Applications Medicine in Drug Discovery · 2020
    2. Inhalation Therapy for Repairing Damaged Elastin Fibers and Decelerating Elastinolysis in Chronic Obstructive Pulmonary Disease Expert Review of Respiratory Medicine · 2018
    3. Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis Matrix Biology · 2005
    4. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    5. Minoxidil Specifically Decreases the Expression of Lysine Hydroxylase in Cultured Human Skin Fibroblasts Biochemical Journal · 1992
    6. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    7. The History of the Development of Minoxidil Clinics in Dermatology · 1988
    8. Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil Journal of Biological Chemistry · 1987
    9. Effects of Minoxidil on Cultured Human Skin Fibroblasts Dermatology · 1987
    10. Severe Hypertension in Children With Renal Disease: Treatment With Minoxidil American Journal of Kidney Diseases · 1983
    11. Reversal of Baldness in Patient Receiving Minoxidil for Hypertension The New England Journal of Medicine · 1980
    12. Minoxidil Southern Medical Journal · 1980