Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

    Allen E. Buhl, Daniel Waldon, Carolyn D. Baker, Garland A. Johnson
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    TLDR Minoxidil sulfate stimulates hair growth.
    This study from 1990 found that minoxidil sulfate, a metabolite of minoxidil, is the active ingredient responsible for stimulating hair growth. The study demonstrated that sulfation of minoxidil is a critical step for its effects on hair growth and that drugs that block the formation of minoxidil sulfate also block the activity of the parent drug. The study suggests that other drugs that can be metabolized to an active sulfate might be expected to directly affect hair follicles.
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      community Minoxidil Sulfate makes everyone a responder

      in Research/Science  260 upvotes 10 months ago
      Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

      community Is this Better Than Topical Minoxidil? Topical Diazoxide

      in Research/Science  6 upvotes 5 months ago
      Topical diazoxide may be a promising hair regrowth treatment, especially for those who don't respond to minoxidil, as it activates potassium channels without needing sulfation. It appears safe for topical use, avoiding systemic effects seen in oral use.

      community Comprehensive Microneedling Guide

      in Microneedling  295 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

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