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GlossarySulfation

biochemical process adding sulfate groups to molecules

Sulfation is a biochemical process where a sulfate group (SO₄) is added to molecules, such as hormones, drugs, or neurotransmitters. This modification often alters the molecule's function, solubility, or how it is metabolized and excreted by the body. In the context of hair biology, sulfation can influence the activity of certain proteins and enzymes involved in hair growth and health.

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research Sulfotransferases, Sulfatases, and Formylglycine-Generating Enzymes: A Sulfation Fascination

83 citations, July 2008 in “Current Opinion in Chemical Biology”

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

research Sulfation of Minoxidil by Liver Sulfotransferase

66 citations, September 1982 in “Biochemical Pharmacology”

Liver enzyme helps minoxidil work better for blood vessel relaxation.

research Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases

59 citations, February 1998 in “Chemico-Biological Interactions”

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

research Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil

53 citations, January 1993 in “Biochemical Pharmacology”

Minoxidil needs activation to work, and minoxidil sulfate helps with hair growth and blood pressure.

research Sulfation of Minoxidil by Human Platelet Sulfotransferase

39 citations, November 1987 in “Clinica Chimica Acta”

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 410 upvotes 2 weeks ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community Minoxidil Sulfate makes everyone a responder

in Research/Science 260 upvotes 7 months ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

in Research/Science 77 upvotes 10 months ago

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 3 months ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community just saw my hair under harsh sunlight and devastated..

in Chat 121 upvotes 7 months ago

The conversation discusses hair loss struggles and treatments, including oral minoxidil, oral finasteride, and RU58841. Users share experiences and advice, suggesting options like topical minoxidil, microneedling, hair transplants, and scalp micropigmentation.

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