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    GlossarySulfation

    biochemical process adding sulfate groups to molecules

    Sulfation is a biochemical process where a sulfate group (SO₄) is added to molecules, such as hormones, drugs, or neurotransmitters. This modification often alters the molecule's function, solubility, or how it is metabolized and excreted by the body. In the context of hair biology, sulfation can influence the activity of certain proteins and enzymes involved in hair growth and health.

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      community Is this Better Than Topical Minoxidil? Topical Diazoxide

      in Research/Science  6 upvotes 9 months ago
      Topical diazoxide may be a promising hair regrowth treatment, especially for those who don't respond to minoxidil, as it activates potassium channels without needing sulfation. It appears safe for topical use, avoiding systemic effects seen in oral use.
      Can liver problems be associated with response to the oral minoxidil?

      community Can liver problems be associated with response to the oral minoxidil?

      in Research  147 upvotes 5 days ago
      Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.

      community Minoxidil Sulfate makes everyone a responder

      in Research/Science  261 upvotes 1 year ago
      Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.