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Glossary Sulfation

biochemical process adding sulfate groups to molecules

Sulfation is a biochemical process where a sulfate group (SO₄) is added to molecules, such as hormones, drugs, or neurotransmitters. This modification often alters the molecule's function, solubility, or how it is metabolized and excreted by the body. In the context of hair biology, sulfation can influence the activity of certain proteins and enzymes involved in hair growth and health.

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community My summation of PP405 - looks promising

210 upvotes 1 year ago

PP405 shows promise for hair regrowth by manipulating stem cell characteristics and lactate dehydrogenase, with Phase 2a trials pending. Google Ventures' $15M investment suggests confidence, but results and market availability remain uncertain.

community Is this Better Than Topical Minoxidil? Topical Diazoxide

6 upvotes 1 year ago

Topical diazoxide may be a promising hair regrowth treatment, especially for those who don't respond to minoxidil, as it activates potassium channels without needing sulfation. It appears safe for topical use, avoiding systemic effects seen in oral use.

community Minoxidil Sulfate makes everyone a responder

258 upvotes 1 year ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

community Will oral minoxidil work if you're missing the SULT1A1 enzyme?

in Minoxidil 12 upvotes 1 month ago

Oral minoxidil can still work without the SULT1A1 enzyme because the liver has enough of it, but its effectiveness on the scalp depends on transporters. Oral minoxidil generally does not affect blood pressure at low doses.

community is there anything that stops hair loss?

8 upvotes 1 year ago

A user is experiencing rapid hair loss and has been diagnosed with telogen effluvium by multiple dermatologists, but doubts the diagnosis due to the severity and speed of the hair loss. They are considering various treatments like spironolactone, estradiol, and possibly finasteride, while also exploring the possibility of hormonal imbalances or autoimmune issues.

community Aminexil, Nanoxidil, Stemoxydine and Kopexil. Anyone use them?

1 upvotes 9 years ago

Aminexil, nanoxidil, stemoxydine, and kopexil are discussed as alternatives to minoxidil for hair growth, with concerns about dependence. Minoxidil is noted for its effectiveness in transitioning hair growth phases, but dependence is mainly linked to androgenic alopecia.

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

74 upvotes 2 years ago

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

community Balding young is one of the most unfair things ever

371 upvotes 2 months ago

A 19-year-old is frustrated with early balding and is using finasteride and minoxidil, hoping for improvement. Others share similar experiences and suggest additional treatments like microneedling and ketoconazole shampoo.

community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

114 upvotes 1 year ago

The conversation discusses the potential of PP405 as a hair loss treatment, with some users expressing skepticism and others hopeful about its development. There is also mention of other treatments like Minoxidil, Finasteride, and Pyrilutamide, with users debating the effectiveness and safety of self-experimentation versus waiting for clinical trial results.

community Does girlfriend ASMR overpower finasteride?

224 upvotes 1 year ago

A humorous discussion on hair loss, suggesting girlfriend ASMR might counteract finasteride's effects, with a proposed experiment involving finasteride, ASMR, and control groups. Participants joke about evolutionary theories, ASMR, and the effects of DHT on balding.

community I’m taking Veradermics VDPHL01 - AMA

in Treatment 174 upvotes 4 months ago

A participant using Veradermics VDPHL01, an extended-release oral minoxidil, experienced significant hair regrowth from Norwood 6 to Norwood 3V without side effects. They plan to use dutasteride after the treatment to maintain results.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community just saw my hair under harsh sunlight and devastated..

in Chat 121 upvotes 1 year ago

The conversation discusses hair loss struggles and treatments, including oral minoxidil, oral finasteride, and RU58841. Users share experiences and advice, suggesting options like topical minoxidil, microneedling, hair transplants, and scalp micropigmentation.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 2 years ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Hair loss journey 3 years in. A public service announcement

137 upvotes 3 months ago

A user shared their 3-year hair loss journey using finasteride, topical and oral minoxidil, and emphasized the importance of addressing scalp conditions like seborrheic dermatitis for better results. They switched from topical to foam minoxidil to reduce scalp irritation and saw improvement in hair density and quality.

community Ggs in the chat. ✌🏼 A year and a half on it.

371 upvotes 4 months ago

The user has been using finasteride 1mg daily, oral minoxidil 5mg daily, and microneedling weekly, experiencing initial side effects like ball pain and weaker erections, which resolved over time. They reported improved hair density after 7 months and recommend adding derma stamping to the routine for better results.

community PP405: Regrows Hair In 8 Weeks. Is This The Miracle Cure?

168 upvotes 7 months ago

PP405 is considered as a potential hair regrowth treatment, but users are skeptical due to past product failures. They compare it to Minoxidil and Finasteride, questioning its effectiveness and the intentions of pharmaceutical companies.

community Excuse me sir, would you like to hear a word about the greatest achievement in human history, finasteride?

513 upvotes 7 months ago

Finasteride and Minoxidil are popular treatments for hair loss, but opinions vary on their effectiveness and side effects. Some users report success, while others experience issues like gynecomastia or sexual dysfunction.

community Natural methods only. Gains or Nah?

10 months ago

The user is attempting to regrow hair using natural methods like microneedling, rosemary oil, and capsaicin tincture, avoiding medications like finasteride and minoxidil due to past health issues. Feedback suggests these methods are ineffective, with many recommending shaving or considering a hair system instead.

community Are Minoxidil & Finasteride/Dutastide the only REAL things that work? Is there anything else I can do for diffuse thinning that actually works on top of these?

13 upvotes 1 year ago

Minoxidil and finasteride are the main effective treatments for hair loss. RU58841 is discussed as a potential option but has concerns about safety and side effects.

community Why do people dismiss laser therapy quickly saying that it doesn’t have strong data yet happily apply microneedling which also lacks strong data

in Research/Science 100 upvotes 1 year ago

Microneedling is preferred over laser therapy for hair loss because it is cheaper and reportedly effective, especially with minoxidil. Laser therapy is seen as costly and less effective.

community Other sulfurtransferase activity upregulator other than Tretinoin?

9 upvotes 3 years ago

The user does not respond well to minoxidil and is seeking an alternative to Tretinoin to upregulate sulfurtransferase activity for hair loss treatment. No specific alternative treatments were mentioned.

community Haircafe video on Min Sulfate, thoughts?

in Research/Science 101 upvotes 10 months ago

Minoxidil sulfate is considered for those unresponsive to regular minoxidil, with some trying a 10% formulation from Folligenz. Concerns exist about the product's stability and transparency, but some users report positive initial results.

community What Determines Sulfotransferase Enzyme Levels In The Body?

in Minoxidil 7 upvotes 1 year ago

Some people have low sulfotransferase enzyme levels, affecting their response to minoxidil. Lifestyle factors, genetics, and diet, like MSM intake, might influence these enzyme levels.

community possible treatment of AGA and change in sebaceous gland condition and oil production using sulfur soap

in Research/Science 4 upvotes 11 months ago

Sulfur soap may help with hair thickening and reducing scalp inflammation, but it can cause dryness. Nizoral, containing ketoconazole, is noted for its potential to reduce seborrheic dermatitis but may also cause scalp dryness and hair loss.

community Increasing activity of the sult1a1 enzyme via alkalizing agent and tretinoin for better response to topical minoxidil

in Research/Science 4 upvotes 2 years ago

Increasing the sult1a1 enzyme on the scalp may improve response to topical minoxidil. The user suggests using a baking soda solution, DMSO, and tretinoin to enhance enzyme activity and minoxidil effectiveness.

community Anyone lose hair on selenium sulfide? (Selsun Blue)

1 upvotes 10 months ago

Selenium sulfide shampoo helped with a sore scalp but may cause hair root damage. Users experienced hair loss with selenium sulfide and ketoconazole, suggesting reducing use if hair loss occurs.

community Switching RU vehicle due to scalp irritation – anyone tried low-EtOH + squalane / emu oil?

in Treatment 2 upvotes 9 months ago

The user is experiencing scalp irritation from using RU58841 with a 70% ethanol and 30% propylene glycol vehicle and is considering switching to a less irritating vehicle, such as 30% ethanol with 70% squalane or emu oil. They are seeking feedback on the effectiveness and irritation levels of these alternative carriers.