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research Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase with minoxidil as the substrate

13 citations , January 1997 in “Biochemical Pharmacology”

This study found that human liver dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of minoxidil, indicating another pathway contributing to its metabolism in humans.

research Simultaneous determination of minoxidil and minoxidil sulfate by high-performance liquid chromatography with UV-detection and its applications

4 citations , May 2020 in “Medicine in Drug Discovery”

This study found that arylsulfatase enzymes in hair follicles can convert the active form of minoxidil back to its inactive form, potentially affecting its effectiveness in treating androgenetic alopecia.

research Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis

87 citations , March 2014 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

This paper discusses X-linked ichthyosis and its genetic causes, focusing on biochemical pathways and their role in epidermal differentiation and barrier function, but it presents no new clinical findings.

research Sulphate conjugation of minoxidil in rat skin

9 citations , March 1993 in “Biochemical Pharmacology”

This study suggests that rat skin may synthesize minoxidil sulphate independently, implying the skin could contribute to minoxidil's hair growth promotion without help from the liver or other organs.

research Sulfation of minoxidil by human platelet sulfotransferase

39 citations , November 1987 in “Clinica Chimica Acta”

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

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community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 6 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community 28M experiencing thinning - first timer here, please help

in Treatments 370 upvotes 10 months ago

A 28-year-old male experiencing hair thinning is considering minoxidil and finasteride. Minoxidil helps regrow hair, while finasteride prevents further loss; both are usually lifelong treatments.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Why do I have the feeling that this subreddit is flooded by Kintor employees?

in Chat 132 upvotes 2 years ago

Users discuss aggressive promotion of Koshine 826, suspecting Kintor employees are behind it. Concerns are raised about its effectiveness, with some preferring alternatives like finasteride and minoxidil.

community Help with female pattern baldness

10 upvotes 2 years ago

A user discusses their struggle with female pattern baldness, mentioning that Minoxidil helped initially but their hair health declined after stopping a specific diet. They seek advice on managing oily, brittle hair and mention using an egg yolk and olive oil mixture as a temporary solution.

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