Characterization of Recombinant Human Liver Dehydroepiandrosterone Sulfotransferase with Minoxidil as the Substrate

    January 1997 in “ Biochemical Pharmacology ”
    Patrick E. Kudlacek, Dahn L. Clemens, Christine M. Halgard … Robert J. Anderson
    Studysummary This study found that human liver dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of minoxidil, indicating another pathway contributing to its metabolism in humans.
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    Research cited in this study 12

    1. Characterization of Recombinant Human Liver Thermolabile Phenol Sulfotransferase with Minoxidil as the Substrate Biochemical and Biophysical Research Communications · 1995
    2. Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil Biochemical Pharmacology · 1993
    3. Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles Journal of Investigative Dermatology · 1991
    4. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    5. Purification and Characterization of Rat Liver Minoxidil Sulphotransferase Biochemical Journal · 1990
    6. Sulfation of Minoxidil by Human Liver Phenol Sulfotransferase Biochemical Pharmacology · 1990
    7. Sulfation of Minoxidil by Human Platelet Sulfotransferase Clinica Chimica Acta · 1987
    8. Sulfation of Minoxidil by Liver Sulfotransferase Biochemical Pharmacology · 1982
    9. Minoxidil and the Treatment of Severe Hypertension The New England Journal of Medicine · 1980
    10. Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory PubMed · 1977
    11. Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory Agent Southern Medical Journal · 1977
    12. The Use of Minoxidil in the Treatment of Severe Essential Hypertension: A Report on 100 Patients Clinical Science · 1976

    Related research 5

    1. The Effect of Topical Minoxidil Treatment on Follicular Sulfotransferase Enzymatic Activity PubMed · 2019
    2. Characterization of Follicular Minoxidil Sulfotransferase Activity in a Cohort of Pattern Hair Loss Patients from the Indian Subcontinent Dermatologic Therapy · 2018
    3. Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases Chemico-Biological Interactions · 1998
    4. Characterization of Recombinant Human Liver Dehydroepiandrosterone Sulfotransferase with Minoxidil as the Substrate Biochemical Pharmacology · 1997
    5. Characterization of Recombinant Human Liver Thermolabile Phenol Sulfotransferase with Minoxidil as the Substrate Biochemical and Biophysical Research Communications · 1995