TLDR Enzyme purified and characterized for minoxidil sulphation in rat liver.
The paper describes the purification and characterization of rat liver minoxidil sulphotransferase (Mx-ST), an enzyme responsible for the sulphation of minoxidil in rat liver cytosol. The enzyme was purified using various chromatography procedures and was found to exist as a homodimer with a subunit molecular mass of approximately 35,000 Da. Mx-ST is related to a family of STs that are capable of sulphating small phenols such as PNP. The study provides information on the purification and characterization of Mx-ST in rat liver tissue.
39 citations,
November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
66 citations,
September 1982 in “Biochemical Pharmacology” Liver enzyme helps minoxidil work better for blood vessel relaxation.
451 citations,
March 2005 in “Endocrine Reviews” The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
19 citations,
October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.
7 citations,
December 2021 in “Pharmaceutics” Natural products like plant extracts can help promote hair growth and could be used to treat hair loss.
4 citations,
January 2015 in “Journal of microbial & biochemical technology” Biotin helps regulate proteins in the blood, which may explain its role in hair growth.
26 citations,
February 2009 in “Drug Development Research” 17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.
