Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

    October 2017 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Domenico Tricarico, Fatima Maqoud, Angela Curci, Giuliamaria Camerino, Nicola Zizzo, Andreas Bernkop-Schnürch, Annalisa Cutrignelli, Valentino Laquintana, Giuseppe Lopalco, Flavia la Forgia, Sergio Fontana, Massimo Franco, Nicola Margiotta
    Image of study
    TLDR The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.
    Five years ago, a study was conducted to evaluate the effectiveness of a gel formulation of minoxidil and hydroxypropyl-β-cyclodextrin (HP-ß-CD) for managing alopecia in male rats. The gel was compared to a traditional minoxidil solution. After 3 weeks, both the minoxidil solution and the minoxidil/HP-ß-CD gel enhanced hair growth by 80.1±2% and 84.3±4% respectively, compared to controls. After 4 weeks, the minoxidil/HP-ß-CD gel significantly enhanced hair length and bulb diameter compared to other groups. The gel also significantly enhanced the mRNA levels of the SUR2 and Kir6.1 subunits of the ATP-sensitive potassium channels and AKT2 compared to other groups. The AR gene was down-regulated compared to controls following treatment with either minoxidil formulations. The study concluded that the minoxidil/HP-ß-CD gel shows a favorable profile for topical long-term use.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community Reql minoxidil vs fake minoxidil (right)

      in Minoxidil  239 upvotes 6 days ago
      Counterfeit minoxidil is a concern, with users suggesting buying from reputable sources like Costco to ensure authenticity. A bleach test can help verify genuine minoxidil.

      community Smoking minoxidil, the theory that changes everything.

      in Minoxidil  591 upvotes 1 week ago
      A user humorously suggested smoking minoxidil in a blunt as an alternative hair growth method, sparking a satirical discussion on unconventional and unsafe ways to use minoxidil. The conversation included various suggestions like oral pills, rectal administration, and other absurd methods, with some users warning against the dangers of such practices.

      community Why don't Minoxidil regenerated hairs become terminal on the head?

      in Minoxidil  102 upvotes 1 week ago
      Minoxidil helps hair growth by increasing blood flow and prolonging the growth phase, but it doesn't address the root cause of hair loss, such as DHT sensitivity. Finasteride can help maintain some gains by blocking DHT, but stopping Minoxidil often leads to hair loss because the new hairs are dependent on it.

      community Be careful with minoxidil, even if it's just foam.

      in Minoxidil  12 upvotes 1 week ago
      Minoxidil caused side effects like chest pain and tinnitus for the user, leading them to stop using it and consider switching to finasteride with microneedling. Other users shared similar experiences with minoxidil, while some reported no issues, highlighting varied individual reactions.

    Similar Research

    5 / 1000+ results