Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

Five years ago, a study was conducted to evaluate the effectiveness of a gel formulation of minoxidil and hydroxypropyl-β-cyclodextrin (HP-ß-CD) for managing alopecia in male rats. The gel was compared to a traditional minoxidil solution. After 3 weeks, both the minoxidil solution and the minoxidil/HP-ß-CD gel enhanced hair growth by 80.1±2% and 84.3±4% respectively, compared to controls. After 4 weeks, the minoxidil/HP-ß-CD gel significantly enhanced hair length and bulb diameter compared to other groups. The gel also significantly enhanced the mRNA levels of the SUR2 and Kir6.1 subunits of the ATP-sensitive potassium channels and AKT2 compared to other groups. The AR gene was down-regulated compared to controls following treatment with either minoxidil formulations. The study concluded that the minoxidil/HP-ß-CD gel shows a favorable profile for topical long-term use.