Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

    October 2017 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Domenico Tricarico, Fatima Maqoud, Angela Curci … Nicola Margiotta
    Studysummary This study found that the MXD/HP-β-CD GEL formulation promoted greater hair growth and improved gene expression related to hair growth in male rats compared to MXD solution or control groups.
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    Research cited in this study 14

    1. Hair Loss And Regeneration Performed On Animal Models Medicine and Pharmacy Reports · 2015
    2. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    3. New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment Drug Development and Industrial Pharmacy · 2014
    4. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
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    6. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008
    7. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
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    9. Potassium Channel Therapeutics at the Bedside Journal of Molecular and Cellular Cardiology · 2005
    10. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    11. Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp British Journal of Dermatology · 1999
    12. Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp Journal of Dermatological Science · 1999
    13. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    14. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984