Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

    October 2017 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Domenico Tricarico, Fatima Maqoud, Angela Curci, Giuliamaria Camerino, Nicola Zizzo, Andreas Bernkop-Schnürch, Annalisa Cutrignelli, Valentino Laquintana, Giuseppe Lopalco, Flavia la Forgia, Sergio Fontana, Massimo Franco, Nicola Margiotta
    Image of study
    TLDR The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.
    Five years ago, a study was conducted to evaluate the effectiveness of a gel formulation of minoxidil and hydroxypropyl-β-cyclodextrin (HP-ß-CD) for managing alopecia in male rats. The gel was compared to a traditional minoxidil solution. After 3 weeks, both the minoxidil solution and the minoxidil/HP-ß-CD gel enhanced hair growth by 80.1±2% and 84.3±4% respectively, compared to controls. After 4 weeks, the minoxidil/HP-ß-CD gel significantly enhanced hair length and bulb diameter compared to other groups. The gel also significantly enhanced the mRNA levels of the SUR2 and Kir6.1 subunits of the ATP-sensitive potassium channels and AKT2 compared to other groups. The AR gene was down-regulated compared to controls following treatment with either minoxidil formulations. The study concluded that the minoxidil/HP-ß-CD gel shows a favorable profile for topical long-term use.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 1000+ results

      community Alternatives to Minox for pet safety

      in Minoxidil  2 upvotes 1 week ago
      The conversation discusses alternatives to minoxidil for beard growth, focusing on a product called Neofollics Beard Growth Serum, which claims to be effective without using minoxidil. Concerns are raised about its ingredients and effectiveness, especially considering pet safety.

      community What ketoconazole shampoo do you use?

      in Ketoconazole  8 upvotes 7 months ago
      Nizoral is commonly used for hair loss and dandruff, but it can cause dryness; users often pair it with conditioners or alternative shampoos. Some also use finasteride, minoxidil, and red light therapy for hair care.

      community Has anyone used minoxidil cream before?

      in Minoxidil  2 upvotes 3 days ago
      A user is considering switching from a 5% minoxidil spray to a minoxidil cream, hoping it will be easier to apply and less greasy. They are seeking feedback on the cream's effectiveness and suitability for sensitive scalps.

    Similar Research

    5 / 1000+ results