The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia

    Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Nunzio Denora, Giuseppe Passantino, Rosa Scala, Annalisa Cutrignelli, Andrea Tinelli, Valentino Laquintana, Flavia la Forgia, Simona Fontana, Massimo Franco, Angela Lopedota, Domenico Tricarico
    Image of study
    TLDR A new gel form of minoxidil is equally effective for hair growth and safer for the heart and other organs than the traditional solution.
    The study compared the effects of a traditional minoxidil solution and a novel hydroxypropyl-β-cyclodextrin-minoxidil gel (MXD/HP-β-CD) on male rats, focusing on cardiovascular and proliferative adverse effects. The traditional solution caused cardiac hypertrophy, hypotension, increased serum natriuretic peptides and potassium ion levels, elevated liver biomarkers, and renal cancer, while the novel gel formulation showed a better safety profile with less severe effects. The study included 20 rats divided into four experimental groups, with additional rats for specific monitoring, and used various methods for assessment. The MXD/HP-β-CD gel formulation was found to be equally effective in promoting hair growth with fewer adverse effects, suggesting it may be a safer alternative for treating alopecia.
    Discuss this study in the Community →

    Research cited in this study

    32 / 32 results

    Related Community Posts Join

    6 / 1000+ results

      community What ketoconazole shampoo do you use?

      in Ketoconazole  8 upvotes 1 month ago
      Nizoral is commonly used for hair loss and dandruff, but it can cause dryness; users often pair it with conditioners or alternative shampoos. Some also use finasteride, minoxidil, and red light therapy for hair care.

      community How you guys use minoxidil? Need advice.

      in Minoxidil  5 upvotes 3 days ago
      A 23-year-old with Norwood 4 hair loss is using minoxidil, finasteride, oral minoxidil, a multivitamin, and derma rolling, seeking advice on whether to increase minoxidil usage despite cost concerns. A dermatologist recommended the regimen, and the user added derma rolling and tretinoin.

      community Minoxidil with Tretinoin together

      in Minoxidil  8 upvotes 5 days ago
      Combining tretinoin with minoxidil may improve absorption by exfoliating the scalp, but results vary. Users suggest starting with low frequency to avoid irritation, and some recommend additional treatments like finasteride or microneedling.

      community Genuine Minoxidil Sanity Check-Tiktok Shops

      in Minoxidil  189 upvotes 5 days ago
      A user bought Kirkland Minoxidil from a TikTok shop and sought confirmation of its authenticity through a bleach test, which some users warned could be dangerous. Many participants advised against buying from TikTok due to the risk of fakes, suggesting alternatives like buying from Costco or reputable online pharmacies.

    Related Research

    6 / 6 results