Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery

October 2016 in “ European Journal of Pharmaceutical Sciences ”

Maíra N. Pereira, Heidi Luise Schulte, Natane C.B. Duarte, Eliana Martins Lima, Livia L. Sa-Barreto, Tais Gratieri, Angel Concheiro

solid effervescent formulations topical minoxidil follicular casts viable skin Rogaine

Studysummary This study found that a novel effervescent formulation significantly increased minoxidil sulphate accumulation in hair follicles and skin compared to a standard minoxidil solution.

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Research cited in this study

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research Iontophoresis of Minoxidil Sulphate Loaded Microparticles: A Strategy for Follicular Drug Targeting?

25 citations , July 2015 in “Colloids and Surfaces B: Biointerfaces”

This study found that microencapsulation combined with iontophoresis can significantly enhance the delivery of minoxidil sulphate to hair follicles, suggesting a synergetic approach for topical drug targeting.

research Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles

77 citations , January 2015 in “International Journal of Biological Macromolecules”

This study developed minoxidil sulphate-loaded chitosan nanoparticles that doubled drug delivery to hair follicles in vitro compared to a control solution, suggesting potential for improved alopecia treatment.

research Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle

59 citations , January 2015 in “Nanoscale”

In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.

research Iontophoresis-Targeted, Follicular Delivery of Minoxidil Sulfate for the Treatment of Alopecia

32 citations , March 2013 in “Journal of Pharmaceutical Sciences”

This study observed that iontophoresis significantly improved the delivery of minoxidil sulfate to hair follicles compared to passive methods, suggesting potential benefits for alopecia treatment.

research Chitosan Microparticles for Sustaining the Topical Delivery of Minoxidil Sulphate

45 citations , August 2011 in “Journal of Microencapsulation”

This study found that chitosan microparticles containing minoxidil sulphate sustained its release and may hold potential for targeted topical treatment of alopecia.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations , February 2011 in “Journal of Controlled Release”

This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

research Targeting to the Hair Follicles: Current Status and Potential

142 citations , January 2010 in “Journal of dermatological science”

This review covers follicle-targeting drug delivery systems, exploring their potential for improving localized and systemic therapies, and highlights the need for further research into follicle penetration mechanisms.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study introduces a novel non-invasive method called "differential stripping" to quantify the penetration of topically applied substances into hair follicles.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations , February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

166 citations , November 1990 in “Journal of Investigative Dermatology”

Minoxidil sulfate stimulates hair growth.