Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies

    January 2018 in “ Skin pharmacology and physiology ”
    Eman Abd, Heather A. E. Benson, Michael S. Roberts, Jeffrey E. Grice
    Studysummary This study found that nanoemulsion formulations with oleic acid or eucalyptol significantly enhanced the delivery and retention of caffeine through hair follicles and surrounding skin regions.
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    Research cited in this study 15

    1. Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting Pharmaceutics · 2018
    2. Do Nanoparticles Have a Future in Dermal Drug Delivery? Journal of Controlled Release · 2016
    3. Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination Journal of controlled release · 2015
    4. Investigation of Follicular and Non-Follicular Pathways for Polyarginine and Oleic Acid-Modified Nanoparticles Pharmaceutical research · 2012
    5. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    6. Methods for Quantifying Intrafollicular Drug Delivery: A Critical Appraisal Expert Opinion on Drug Delivery · 2010
    7. Targeting to the Hair Follicles: Current Status and Potential Journal of dermatological science · 2010
    8. Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro Journal of Pharmaceutical Sciences · 2009
    9. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    10. Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery AAPS PharmSciTech · 2009
    11. Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions European journal of pharmaceutics and biopharmaceutics · 2009
    12. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    13. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    14. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    15. Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro Journal of drug targeting · 2002