Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies

    January 2018 in “ Skin pharmacology and physiology ”
    Eman Abd, Heather A. E. Benson, Michael S. Roberts, Jeffrey E. Grice
    Image of study
    TLDR Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.
    In a 2018 study, researchers found that nanoemulsion formulations containing penetration enhancers oleic acid (OA) and eucalyptol (EU) significantly increased the permeation of caffeine through human skin. The study showed a 36- to 49-fold increase in caffeine permeation in skin with open and untreated hair follicles compared to control. Specifically, when follicles were open, the follicular route contributed to over 50% of caffeine permeation for both OA and EU nanoemulsions. Additionally, these nanoemulsions increased caffeine retention in open follicles by 3.4- to 4-fold. The study, which had a sample size of n = 3, concluded that nanoemulsions can effectively deliver caffeine into and through hair follicles, suggesting their potential for targeted dermatotherapy. However, larger studies are needed to confirm these findings. The research was supported by the National Health and Medical Council of Australia and approved by the University of Queensland Human Research Ethic Committee.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 742 results

      community The real stack, the only things you really need.

      in Treatment  1 upvotes 11 months ago
      The conversation discusses a hair loss prevention regimen using a custom topical treatment with Dutasteride, Minoxidil, Latanoprost, Cetirizine, Tretinoin, Vitamin D3, and caffeine, along with supplements like iron, selenium, vitamin D, and vitamin B. The user advises against expensive treatments like LLLT caps and unnecessary natural supplements.

      community Minoxidil & Tretinoin for non responder. results

      in Minoxidil  8 upvotes 4 years ago
      A user asked if anyone who didn't respond to minoxidil saw improvement after adding tretinoin. One person replied they saw hair growth on their hairline after using a combination of minoxidil, finasteride, and tretinoin, suggesting tretinoin may have made them respond to minoxidil.

      community is it possible of this change in like.. a month???

      in Progress Pictures  6 upvotes 2 years ago
      The user noticed significant hair improvement in a month after stopping caffeine and regularly using minoxidil and a 0.05% finasteride with 6% minoxidil topical solution. They question if the changes are due to the end of shedding and the start of new growth.

      community Helicobacter's concocted serum v1

       6 upvotes 7 years ago
      A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

    Similar Research

    5 / 723 results