Do Nanoparticles Have a Future in Dermal Drug Delivery?

    September 2016 in “ Journal of Controlled Release ”
    Alexa Patzelt, Wing Cheung Mak, Sora Jung … Jürgen Lademann
    Studysummary Nanoparticles can improve drug delivery to hair follicles but struggle to penetrate deeper skin layers.
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    Research cited in this study 13

    1. Tight Junctions Form a Barrier in Porcine Hair Follicles European journal of cell biology · 2015
    2. Triggered Release of Model Drug from Gold Nanoparticle-Doped Bovine Serum Albumin Nanocarriers in Hair Follicles Using Infrared A Radiation Acta Biomaterialia · 2015
    3. Quantification of Nanoparticle Uptake Into Hair Follicles in Pig Ear and Human Forearm Journal of Controlled Release · 2014
    4. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    5. In Vivo Investigation of the Efficiency of a Nanoparticle-Emulsion Containing Polihexanide on Human Skin European journal of pharmaceutics and biopharmaceutics · 2012
    6. Triggering of Drug Release of Particles in Hair Follicles Journal of controlled release · 2012
    7. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    8. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    9. Determination of the Cuticle Thickness of Human and Porcine Hairs and Their Potential Influence on the Penetration of Nanoparticles into the Hair Follicles Journal of Biomedical Optics · 2009
    10. Evaluation of the Permeability of Hair Growing Ingredient Encapsulated PLGA Nanospheres to Hair Follicles and Their Hair Growing Effects Bioorganic & Medicinal Chemistry Letters · 2007
    11. Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation Pharmaceutical Development and Technology · 2007
    12. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of controlled release · 2004
    13. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of Controlled Release · 2004