Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation

    January 2007 in “ Pharmaceutical Development and Technology ”
    Rajesh Kumar, Bhupinder Singh, Gautam Bakshi, Om Prakash Katare
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    TLDR Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.
    This document discusses the development of liposomal systems of Finasteride for topical applications. The study found that liposomes can enhance the follicular delivery of finasteride, a drug used to treat hair loss, by improving its permeation and deposition in the skin. The liposomal system improved the solubility and permeability of finasteride, making it a promising option for topical treatment of androgenetic alopecia. The researchers optimized the liposomal formulations with respect to drug payload, entrapment efficiency, and size by formulating different vesicular compositions under different process conditions. The study concluded that liposomal systems of finasteride could be a promising approach for topical applications.
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      community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

      in Minoxidil  178 upvotes 2 months ago
      Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

      community Topical Minoxidil is a pain in the ass for diffuse thinners

      in Minoxidil  95 upvotes 2 years ago
      Topical minoxidil being a difficult product to apply, with users considering finasteride, RU58841, and oral minoxidil as alternative treatments for diffuse thinning hair. Other advice includes shaving the head in the first 3 months of using minoxidil and finding ways to apply it without saturating the hair.

      community Topical finasteride has affected my hormones

      in Finasteride/Dutasteride  27 upvotes 1 year ago
      A 21-year-old experienced hormone changes after using self-made topical finasteride for hair loss, including a 20% decrease in DHT, a 47% increase in testosterone, and a 39% increase in estradiol. The user previously used minoxidil and microneedling but is now seeking ways to balance hormones, possibly through supplements or dosage adjustments.

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