Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes

June 2006 in “ International Journal of Pharmaceutics ”

Majid Tabbakhian, Naser Tavakoli, Mahmoud Reza Jaafari, Saeid Daneshamouz

finasteride liposomes niosomes pilosebaceous unit topical delivery hair follicles hydroalcoholic solution Propecia

TLDR Liposomes and niosomes improve finasteride delivery for hair loss treatment.

The study investigated the use of liposomes and niosomes to enhance the delivery of finasteride to hair follicles. The results showed that liquid-state liposomes and niosomes were able to deposit significantly higher amounts of the applied dose to the pilosebaceous unit compared to gel-state vesicles or hydroalcoholic solution. The study suggests that the use of liposomes and niosomes could be a promising approach for delivering finasteride topically to treat hair loss.

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Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

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Research cited in this study

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

research Use of Finasteride in the Treatment of Men With Androgenetic Alopecia

research Permeant Lipophilicity and Vehicle Composition Influence Accumulation of Dyes in Hair Follicles of Human Skin

research Penetration and Distribution of Three Lipophilic Probes in Human Skin Focusing on the Hair Follicle

research Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

research Treatments for Androgenetic Alopecia and Alopecia Areata

research Finasteride in the Treatment of Men with Androgenetic Alopecia

research Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes

research Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course

research Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

research Percutaneous Absorption of a New Antiandrogen Included in Liposomes or in Solution

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

research A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women

research Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism

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