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Glossary Pilosebaceous Unit

complex skin structure including hair follicle and sebaceous gland

The pilosebaceous unit is a complex structure in the skin that includes a hair follicle, a sebaceous (oil) gland, and an arrector pili muscle. This unit is responsible for producing and growing hair, as well as secreting sebum, an oily substance that helps lubricate and protect the skin. Understanding the pilosebaceous unit is crucial for studying conditions like acne and alopecia, which involve disruptions in this system.

Research

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research The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

130 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that estrogen receptor beta, not alpha, is the main mediator of estrogen action in human skin and hair follicles, suggesting a distinct role in these tissues.

research Hormones and the pilosebaceous unit

97 citations , March 2009 in “Dermato-endocrinology”

This review explores the role of hormones in pilosebaceous units and associated skin disorders, focusing on androgen action, without presenting new clinical findings.

research Hirsutism and the Variable Response of the Pilosebaceous Unit to Androgen

56 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.

research Traumatic Alopecia in Trichotillomania: a Pathogenic Interpretation of Histologic Lesions in the Pilosebaceous Unit^*

37 citations , April 1977 in “Journal of Cutaneous Pathology”

This study found that specific histologic features in skin biopsies can help support a diagnosis of traumatic alopecia (trichotillomania), but not all markers are distinct to the condition.

research Development and characterization of minoxidil-loaded liposomal system for delivery to pilosebaceous units

34 citations , March 2004 in “Journal of Liposome Research”

This study found that neutral liposomes were most effective at delivering minoxidil into pilosebaceous units compared to other tested formulations.

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Community Join

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community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 8 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 1 year ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 6 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

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