Triggered Release of Model Drug from Gold Nanoparticle-Doped Bovine Serum Albumin Nanocarriers in Hair Follicles Using Infrared A Radiation

November 2015 in “ Acta Biomaterialia ”

Jürgen Lademann, Heike Richter, Fanny Knorr, Alexa Patzelt, Maxim E. Darvin, E. Rühl, Kwan Yee Cheung, Kwok Kei Lai, R. Renneberg, Wing Cheung Mak

gold nanoparticles bovine serum albumin infrared A radiation hair follicles ex vivo porcine skin model plasmonic heating targeted drug delivery follicular structures skin damage AuNPs BSA IRA radiation

Studysummary This study found that water-filtered infrared A radiation can induce the release of a model drug from gold nanoparticle-doped particles in hair follicles in an ex vivo porcine skin model, suggesting feasibility for follicular drug delivery systems. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrated the photo-activated release of the model drug fluorescein isothiocyanate (FITC) from gold nanoparticle-doped bovine serum albumin (AuNP-doped BSA) particles using water-filtered infrared A (IRA) radiation in hair follicles of an ex vivo porcine skin model. The IRA radiation caused plasmonic heating of the AuNPs, leading to the partial decomposition of the albumin particles and subsequent drug release. Control particles without AuNPs showed insignificant release. This method showed potential for targeted drug delivery in follicular structures, although the risk of skin damage from repeated high infrared dosages was noted. Future research should explore the use of lower infrared dosages for repeated therapeutic applications.

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