TLDR Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.
The study investigated the use of nanoparticles for transcutaneous vaccine delivery targeting antigen-presenting cells (APCs) in human skin. It was found that only 40 nm nanoparticles, not 750 or 1,500 nm ones, could penetrate deeply into vellus hair openings and the follicular epithelium, effectively entering epidermal Langerhans cells (LCs). This suggests that 40 nm nanoparticles could be efficiently used to deliver vaccine compounds via hair follicles into cutaneous APCs, potentially improving immune responses for chronic diseases like HIV and tuberculosis.
109 citations,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Targeting hair follicles can improve skin treatments and reduce side effects.
316 citations,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
27 citations,
December 2002 in “Journal of dermatological science” Merkel cells and Langerhans cells in hair follicles are closely connected and may interact.
211 citations,
February 2009 in “European journal of pharmaceutics and biopharmaceutics” Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.
42 citations,
January 2021 in “Journal of Clinical Medicine” Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.
119 citations,
December 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Nanoparticles can deliver vaccines through hair follicles, triggering immune responses and providing protection.
38 citations,
May 2015 in “Journal of controlled release” IMSG nanoparticles improve vaccine delivery and immune response through hair follicles.
The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.
